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Basic and Clinical Neuroscience، جلد ۱۲، شماره ۱، صفحات ۷۹-۸۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Bioinformatics Investigation and Contribution of Other Chromosomes Besides Chromosome 21 in the Risk of Down Syndrome Development
چکیده انگلیسی مقاله Introduction: Down syndrome as a genetic disorder is a popular research topic in molecular studies. One way to study Down syndrome is via bioinformatics.  Methods: In this study, a gene expression profile from a microarray study was selected for more investigation. Results: The study of Down syndrome patients shows specific genes with differential expression and network centrality properties. These genes are introduced as RHOA, FGF2, FYN, and CD44, and their level of expression is high in these patients.  Conclusion: This study suggests that besides chromosomes 21, there are additional contributing chromosomes to the risk of Down syndrome development. Besides, these genes could be used for clinical studies after more analysis.
کلیدواژه‌های انگلیسی مقاله Down Syndrome, Protein interaction Maps, Transcriptome, Differentially Expressed Genes, Biological Process
نویسندگان مقاله | Mona Zamanian Azodi
Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Mostafa Rezaei Tavirani
Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Majid Rezaei Tavirani
Department of Surgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.


| Mohammad Rostami Nejad
Research Institute For Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-941-6&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Behavioral Neuroscience
نوع مقاله منتشر شده Original
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