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Basic and Clinical Neuroscience، جلد ۱۱، شماره ۴، صفحات ۴۵۷-۴۶۴
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عنوان انگلیسی The Effects of 3,4-methylenedioxy- methamphetamine on Neurogenesis in the Hippocampus of Male Rats
چکیده انگلیسی مقاله Introduction: The administration of 3,4-methylenedioxymethamphetamine (MDMA) or ecstasy causes memory impairment, whereas neurogenesis improves memory and learning. Hence, this study evaluated the effects of MDMA on neurogenesis in the hippocampus of male rats. Methods: Adult male Wistar rats received Intraperitoneal (IP) injections of MDMA (10 mg/kg). We assessed nestin, sex-determining region Y-box 2 (Sox2), and NeuroD expressions according to the immunohistochemistry analyses.  Results: MDMA reduced the expressions of nestin, Sox2, and NeuroD compared with the control groups. The reduction in NeuroD expression was age-related.  Conclusion: MDMA possibly has negative effects on neurogenesis, which specifically results from impaired survival of newborn cells.
کلیدواژه‌های انگلیسی مقاله N-Methyl-3,4-methylenedioxyamphetamine, Hippocampus, Nestin, Sox2 Protein, NeuroD Protein
نویسندگان مقاله | Sara Soleimani Asl
Endometrium and Endometriosis Research Centre, Hamadan University of Medical Sciences, Hamadan, Iran.


| Fahimeh Ghasemi Moravej
Endometrium and Endometriosis Research Centre, Hamadan University of Medical Sciences, Hamadan, Iran.


| Golshad Kowsari
School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.


| Mohammad Hassan Farhadi
Researcher of Subsance Abuse and Dependence Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.


| Bagher Pourhaydar
Department of Anatomy, Neurophysiology Research Center, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.


| Hatef Ghasemi Hamidabadi
Department of Anatomy and Cell Biology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.


| Mehdi Mehdizadeh
Department of Anatomy, Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-618-6&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Behavioral Neuroscience
نوع مقاله منتشر شده Original
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