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Basic and Clinical Neuroscience، جلد ۱۱، شماره ۴، صفحات ۴۷۳-۴۸۰
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چکیده فارسی مقاله
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عنوان انگلیسی Role of Nitric Oxide in the Antipruritic Effect of WIN 55,212-2, a Cannabinoid Agonist
چکیده انگلیسی مقاله Introduction: For centuries, cannabinoids are known to be effective in pain relief. Itch is an unpleasant sensation that provokes a desire to scratch. Since itch and pain are two sensations sharing a lot in common, we aimed to investigate whether the cannabinoid agonist WIN 55,212-2 reduces serotonin-induced scratching behavior and also observe whether modulation of nitric oxide (NO) production mediates the antipruritic effect of WIN 55,212-2. Methods: Scratching behavior is induced by intradermal injection of serotonin (50 µg/50 µL/mouse) to BALB/c mice. The cannabinoid agonist WIN 55,212-2 (1, 3, 10 mg/kg, IP) was given 30 min before serotonin injection. To observe the effect of NO modulation on the antipruritic effect of cannabinoids, the endothelial nitric oxide synthase (NOS) inhibitor L-NAME (3 mg/kg, IP), the neuronal NOS inhibitor 7-nitroindazole (3 mg/kg, IP), and the NO precursor L-arginine (100 mg/kg, IP) were administered together with WIN 55,212-2.  Results: WIN 55,212-2 reduced serotonin-induced scratches at higher doses (3, 10 mg/kg; P< 0.0001). The endothelial NOS inhibitor L-NAME, the neuronal NOS inhibitor 7-nitroindazole, and the nitric oxide precursor L-arginine did not influence the antipruritic action of WIN 55,212-2. When NO modulators were used alone, only the neuronal NOS inhibitor 7-nitroindazole attenuated serotonin-induced scratches (P< 0.0001). Conclusion: Our findings indicate that exogenous cannabinoids may attenuate serotonin-induced scratches and NO does not mediate the antipruritic effect of WIN 55,212-2. On the other hand, neuronal NOS inhibition may play a role in the production of serotonin-induced scratches.
کلیدواژه‌های انگلیسی مقاله Cannabinoid system, Nitric oxide, Pruritus, Serotonin, WIN 55,212-2
نویسندگان مقاله | Oyku Zeynep Gercek
Department of Medical Pharmacology, Faculty of Medicine, Trakya University, Turkey.


| Busra Oflaz
Department of Medical Pharmacology, Faculty of Medicine, Trakya University, Turkey.


| Neslihan Oguz
Department of Medical Pharmacology, Faculty of Medicine, Trakya University, Turkey.


| Koray Demirci
Department of Medical Pharmacology, Faculty of Medicine, Trakya University, Turkey.


| Ozgur Gunduz
Department of Medical Pharmacology, Faculty of Medicine, Trakya University, Turkey.


| Ahmet Ulugol
Department of Medical Pharmacology, Faculty of Medicine, Trakya University, Turkey.
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-1348-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Behavioral Neuroscience
نوع مقاله منتشر شده Original
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