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Basic and Clinical Neuroscience، جلد ۱۱، شماره ۳، صفحات ۳۳۳-۳۴۸
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عنوان انگلیسی Low-frequency Stimulation Decreases Hyperexcitability Through Adenosine A1 Receptors in the Hippocampus of Kindled Rats
چکیده انگلیسی مقاله Introduction: In this study, the role of A1 adenosine receptors in improving the effect of Low-Frequency Electrical Stimulation (LFS) on seizure-induced hyperexcitability of hippocampal CA1 pyramidal neurons was investigated. Methods: A semi-rapid hippocampal kindling model was used to induce seizures in male Wistar rats. Examination of the electrophysiological properties of CA1 pyramidal neurons of the hippocampus using whole-cell patch-clamp recording 48 h after the last kindling stimulation revealed that the application of LFS as two packages of stimulations at a time interval of 6 h for two consecutive days could significantly restore the excitability CA1 pyramidal neurons evidenced by a decreased in the of the number of evoked action potentials and enhancement of amplitude, maximum rise slope and decay slope of the first evoked action potential, rheobase, utilization time, adaptation index, first-spike latency, and post-AHP amplitude. Selective locked of A1 receptors by the administration of 8-Cyclopentyl-1,3-dimethylxanthine (1 μM, 1 μl, i.c.v.) before applying each LFS package, significantly reduced LFS effectiveness in recovering these parameters.  Results: On the other hand, selective activation of A1 receptors by an injection of N6-cyclohexyladenosine (10 μM, 1 μl, i.c.v.), instead of LFS application, could imitate LFS function in improving these parameters.  Conclusion: It is suggested that LFS exerts its efficacy on reducing the neuronal excitability, partially by activating the adenosine system and activating its A1 receptors.
کلیدواژه‌های انگلیسی مقاله Seizure, Kindling, Low-frequency stimulation, Electrophysiological Properties, Adenosine A1 Receptors
نویسندگان مقاله | Amir Shojaee
Department of Physiology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.


| Parvin Zareian
Department of Physiology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.


| Javad Mirnajafi-Zadeh
Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-1713-1&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Cellular and molecular Neuroscience
نوع مقاله منتشر شده Original
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