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Iranian Journal of Pediatric Hematology and Oncology، جلد ۱۱، شماره ۳، صفحات ۱۹۲-۱۹۷
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عنوان انگلیسی Cerebral hemodynamic in patients with major β-Thalassemia using transcranial Doppler sonography
چکیده انگلیسی مقاله Background: β-thalassemia, a severe form of anemia, is an inherited blood disorder characterized by growth retardation, splenomegaly, and bone abnormalities. Complications related to treatment-induced iron overload also affect the quality of life of patients with major β-thalassemia. Some recent studies indicated cerebral hemodynamic disorders and increased risk of stroke in these patients. The aim of this study was to evaluate mean flow velocity (MFV) in some cerebral arteries of patients with major thalassemia using transcranial Doppler ultrasonography.  Materials and Methods: In this cross-sectional study, 26 patients with major thalassemia were investigated. The definitive diagnosis was based on serum hemoglobin electrophoresis. Transcranial Doppler ultrasonography was performed in patients and MFV of internal carotid, anterior cerebral, and middle cerebral. Posterior cerebral arteries were measured. Demographic characteristics, duration of treatment, number of blood transfusions per month, the interval between the last blood transfusion, and the ultrasonography were recorded and analyzed statistically. Results: Ten female and 16 male patients participated in this study. Results showed that 57.7% of patients had a hemodynamic abnormality in at least one vessel. The abnormality was significantly higher in the anterior and middle cerebral arteries (p< 0.001 and p=0.005, respectively). Among the variables evaluated, age was significantly associated with hemodynamic dysfunction. This relationship remained significant after using the logistic regression analysis (p=0.0267). Conclusions: Some patients with major thalassemia have a cerebral hemodynamic abnormality. Aging is associated with the higher frequency of this abnormality. 
کلیدواژه‌های انگلیسی مقاله Major thalassemia, Cerebral, Hemodynamic
نویسندگان مقاله | Farhad Iranmanesh
Neurology Research Center, Kerman University of Medical Sciences, Kerman, Iran.


| Azam Hashemi
Hematology and Oncology research center , Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Hematology and Oncology research center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

| Alireza Jenabzade
Hematology and Oncology research center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


| Mahvash Akhavanghalibaf
Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


| Tania Dehesh
Department of Biostatistics and Epidemiology, Kerman University of Medical Sciences, Kerman.


| Marzieh Abutorabi-zarchi
Shahid Sadoughi University of Medical Sciences, Yazd, Iran
نشانی اینترنتی http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-842-1&slc_lang=en&sid=1
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