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Iranian Journal of Pediatric Hematology and Oncology، جلد ۱۱، شماره ۲، صفحات ۱۳۴-۱۴۱
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عنوان انگلیسی Different Biomarkers of Acute kidney Injury in Cancer Patients
چکیده انگلیسی مقاله Acute Kidney Injury (AKI) occurs if the kidneys suddenly lose their ability to remove waste products. When the kidneys lose their ability to filter, dangerous levels of waste products can accumulate, which can upset the chemical composition of the blood and urine. Chemotherapy is one of the methods used to treat or temporarily reduce cancer by using certain medications. The main task of this treatment is to kill cancer cells without seriously damaging the surrounding tissues. However, this type of treatment also has destructive effects on healthy cells and tissues in the body. Researchers studying cancer patients undergoing chemotherapy found that people undergoing this type of treatment may develop serious kidney problems and be forced to use treatments such as dialysis and kidney transplants. Research showed that people with more severe cancers and advanced tumors are more likely to have acute kidney injury than those with early-stage cancer. AKI biomarkers can be selected from the patient's serum, urine, or body imaging components. Various studies showed that urine is a source of the best markers in AKI. Biomarkers in plasma and urine, such as N-acetyl-β-glucosaminidase, Cystatin-C, β2-microglobulin , Cysteine-Rich Protein, Osteopontin, Fetuin-A, Kidney Injury Molecule-1, Liver-type fatty acid-binding protein, Netrin-1, Neutrophil gelatinase-associated lipocalin, and interleukin-18 are effective tools for early detection of AKI. In this review study, an attempt was made to collect biomarkers related to AKI disease.
کلیدواژه‌های انگلیسی مقاله Acute kidney injury, Chemotherapy, Cancer
نویسندگان مقاله | Reza Kazemi
Department of Urology, Alzahra hospital, Isfahan University of Medical Sciences, Isfahan, Iran


| Shirin Saberianpour
Vascular and endovascular surgery research center, Mashhad university of medical science, Mashhad, Iran


| Hanieh Salehi
Department of Urology, Alzahra hospital, Isfahan University of Medical Sciences, Isfahan, Iran


| Mohammad Hatampour
Department of Urology, Alzahra hospital, Isfahan University of Medical Sciences, Isfahan, Iran


| Elnaz Sheikhpour
Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
نشانی اینترنتی http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-614-1&slc_lang=en&sid=1
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