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Iranian Journal of Pediatric Hematology and Oncology، جلد ۱۱، شماره ۱، صفحات ۲۴-۲۹
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عنوان انگلیسی The correlation between zinc and monocyte phagocytosis in patients with major b-thalassemia
چکیده انگلیسی مقاله Background: Zinc depletion decreases monocyte functions and survival while excessive amount of zinc inhibits monocyte activation. Monocytes shift from conducting intercellular communication to becoming innate immune function as a response. This study aims to examine the influence of zinc status on the monocyte phagocytosis in patients with major beta-thalassemia. Materials and Methods: This study was a randomized-placebo-controlled trial. The patients were randomly assigned into either the zinc-treated group using zinc gluconate 50mg daily or the placebo group. Analysis is based on the 12-weeks observation of the complete blood count, plasma zinc level, and phagocytosis level of monocytes. The phagocytic activity of monocytes was measured using atomic absorption spectroscopy (AAS) or x-ray fluorescence (XRF). The comparisons of the data within each group were analyzed using Mann-Whitney test. Results: The results indicated no significant differences in patients' characteristics; the level of plasma zinc at week 12 in the zinc-treated group (67.41+14.4) was significantly higher than the placebo group (54.37+9.38) (p=0.047). The phagocytosis levels of monocyte at week 12 in zinc-treated group (8.70+4.61) were higher than the placebo groups (8.23+4.22) (p=0.002). The ferritin level of zinc-treated group was higher than placebo group (p=0.084), while high level of ferritin is associated with higher level of monocyte phagocytic activity, the result is statistically significant (p=0.002). The results also showed that higher level of plasma zinc insignificantly correlates with lower phagocytic activity of the monocytes (p=0.059). Conclusion: The immune mechanisms in response to zinc-deficient environment underlying the shifting between adaptive to innate immune response involves multiple molecular components of the immune system and have been attributed to specific features of -thalassemia, in which overall immune activity is decreased even though the phagocytic activity of monocytes is increased.
کلیدواژه‌های انگلیسی مقاله Major beta thalassemia, Monocytes, Phagocytosis, Zinc
نویسندگان مقاله | Teny Tjitra Sari
Hematology-oncology Division, Department of Pediatrics, Cipto Mangunkusumo General Hospital – Faculty of Medicine, University of Indonesia, Jakarta, Indonesia


| Dewi Wulandari
Department of Clinical Pathology, Faculty of MeMedicine, University of Indonesia, Jakarta, Indonesia


| Astrid Indrafebrina Sugianto
University of Indonesia, Jakarta, Indonesia
نشانی اینترنتی http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-636-3&slc_lang=fa&sid=1
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