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International Journal of Organ Transplantation Medicine، جلد ۱۲، شماره ۲، صفحات ۰-۰
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عنوان انگلیسی Impact of G-CSF Therapy on Leukopenia and Acute Rejection Following Kidney Transplantation
چکیده انگلیسی مقاله Background: Leukopenia is a common problem after kidney transplantation. The therapeutic approach typically includes a reduction of the immunosuppressive therapy, which is associated with an increased risk of rejection and allograft loss. Granulocyte colony-stimulating factor (G-CSF) is used as a therapeutic option to raise the leukocyte blood count; however, the effect on acute rejections is controversial. Objective: The goal of this study is to examine the incidence of acute rejections following G-CSF therapy. Methods: We retrospectively evaluated patients with leukopenia following kidney transplantation and G-CSF therapy between January 2007 and December 2017 at our center compared to controls with matched minimal leucocyte blood count in a matched pair analysis. Results: We identified 12 patients, who received G-CSF therapy with a cumulative dose of 10.74 µg/kg body weight over a time frame of 4.3 days. G-CSF therapy resulted in a significantly shorter time period with leucocytes < 3,000/µL (9.5 vs. 16.6 days), but also trended towards an increased risk of rejection within the next 30 days with three patients in the G-CSF group and no patient in the control group (p=0.06) developing an acute biopsy-proven rejection. Infection and mortality rate in the subsequent year were not different between groups. Conclusion: G-CSF therapy decreases the duration of leukopenia post-kidney transplantation, but may also increase the risk of an acute rejection.
کلیدواژه‌های انگلیسی مقاله kidney transplantation, leukopenia, Granulocyte colony-stimulating factor, rejection
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نشانی اینترنتی http://www.ijotm.com/ojs/index.php/IJOTM/article/view/831
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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