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Iranian Journal of Neonatology، جلد ۱۱، شماره ۳، صفحات ۳۱-۳۷
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عنوان انگلیسی Effects of Maternal Immune System Status on Neonate’s Immune System
چکیده انگلیسی مقاله Background: This study evaluated the effects of the maternal immune system stimulation or suppression during the pregnancy on the development of the neonate’s immune system.Methods: A total of 20 female rats were divided into four groups. The groups were treated using Leishmania major, Salmonella typhimurium, Tacrolimus, and sterilized normal saline. The animals were mated after 3-time treatments. The neonate’s humoral immune response, total body, thymus, liver, spleen weight, and histology were determined in this study.Results: The spleen’s mean weight of the two-month-old samples showed a significant reduction in the Salmonella group; in addition, the Tacrolimus group had a significant reduction in liver mean weight. The Salmonella and Tacrolimus groups showed a significant reduction (P≤0.05) in the anti-sheep red blood cells antibody titer.Conclusion: Stimulation or suppression of the immune responses during the pregnancy has significant effects on the neonate’s immune responses, spleen, liver, and thymus development.
کلیدواژه‌های انگلیسی مقاله Immune response, Maternal, neonate, Rat
نویسندگان مقاله | Mohammad Khosravi
Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz,Ahvaz, Iran


| Kaveh Khazaeel
Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz,Ahvaz, Iran


| Mahmoud Khaksary Mahabady
Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz ,Iran. Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran


| Mohammad Amin Behmanesh
Department of Histology, Faculty of Medicine, Dezful University of Medical Sciences, Dezful, Iran
نشانی اینترنتی https://ijn.mums.ac.ir/article_15708.html
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