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Avicenna Journal of Phytomedicine، جلد ۱۲، شماره ۲، صفحات ۱۰۱-۱۰۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Comparison of the effects of alcoholic extract of aerial parts of Anvillea garcinii and atorvastatin on the lipid profile and thyroid hormones in hypercholesterolemic rats
چکیده انگلیسی مقاله Objective: Decreased thyroid hormones along with increased blood fats and overweight, lead to atherosclerosis and eventually cardiovascular disease. The aim of this study was to compare the effects of alcoholic extract of aerial parts of Anvilea garcinii and atorvastatin on the lipid profile and thyroid hormones in hypercholesterolemic rats.Materials and Methods: In this study, 40 male Wistar rats were divided into 5 groups (n=8): control, hypercholesterolemic vehicle and three experimental groups. The control group, received water and normal food daily, the hypercholesterolemic vehicle group received drug solvent (atorvastatin dissolved in distilled water) and three experimental groups received alcoholic extract of A. garcinii (100 and 300 mg/kg) and atorvastatin (10 mg/kg) as gavage. At the end of the 45- day period, blood samples were prepared from all groups and the amount of desired factors was measured and analyzed.Results: The amount of lipid profiles (cholesterol, HDL, LDL, VLDL,TG) and thyroid stimulating hormone in the vehicle group were increased compared to the control group, while the amount of these factors were decreased in the experimental groups compared to the vehicle group. Furthermore, the level of thyroid hormones in the hypercholesterolemic vehicle group was decreased compared to the control group, while the level of these hormones was increased in the experimental groups receiving the extract compared to the vehicle group.Conclusion: Alcoholic extract of A. garcinii aerial parts, may increase thyroid hormones, and sequentially reduce blood lipids; thus, it could be a good candidate for the treatment of hypercholesterolemia and hypothyroidism.
کلیدواژه‌های انگلیسی مقاله Anvillea garcinii, Atorvastatin, Cholesterol, thyroxine, Rat
نویسندگان مقاله | Fatemeh Rasekh
Department of Biology, Payame Noor University, Tehran, Iran


| Zohre Atashi-Nodoshan
Department of Biology, Payame Noor University, Tehran, Iran


| Ali Zarei
Department of Physiology, Estahban School of Paramedical Sciences, School of Nursing Hazrat Zahra (P.B.U.H) Abadeh, Shiraz University of Medical Sciences, Shiraz, Iran


| Amir Abbas Minaeifar
Department of Biology, Payame Noor University, Tehran, Iran


| Saeed Changizi-Ashtiyani
Department of Physiology, Arak University of Medical Sciences, Arak, Iran


| Zahra Afrasyabi
Department of Midwifery, Islamic Azad university of Estahban, Shiraz, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_18130.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Short communication
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