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Avicenna Journal of Phytomedicine، جلد ۱۲، شماره ۱، صفحات ۶۷-۷۶
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عنوان انگلیسی The effects of all trans retinoic acid, vitamin D3 and their combination on plasma levels of miRNA-125a-5p, miRNA-34a, and miRNA-126in an experimental model of diabetes
چکیده انگلیسی مقاله Objective: The purpose of this study was to evaluate the effects of ATRA (all trans retinoic acid), vitamin D3, and their combination on circulating levels of miR (MicroRNA) -125a-5p, miR-126, and miR-34ain diabetic rats.Materials and Methods: Total miRNA was extracted from plasma samples. miRNA expression profiles of 30 rats in five groups were analyzed after 4-week intervention. The expression levels of miRNAs were measured using qRT-PCR.Results: We analyzed the expression of miR-126, miR-125a-5p, and miR-34a in serum among all five groups (p=0.268). The levels of miRNA-126 (p=0.004) and miR-125a-5p (p=0.014) showed a significant difference among our experimental groups. The circulating levels of miR-126 decreased in DC (Diabetic control) group compared to the HC (Healthy control) group (p=0.009). In addition, vitamin D3+ATRA supplementation increased miR-126 expression (p=0.014). Moreover, the levels of miR-125a-5p decreased in the DC group compared to the HC group (p=0.019).Conclusion: The expression of miR-126 and miR-125a-5p decreased in diabetic rats. Also, vitamin D3+ATRA can be considered a new therapeutic agent that can elevate miR-126 expression and prevent diabetes-related cardiovascular complications.
کلیدواژه‌های انگلیسی مقاله Plasma miRNAs, miR-126, Type 2 diabetes, Cardiovascular Disease
نویسندگان مقاله | Mohammad Sharifzadeh
Department of Clinical Nutrition, School of Nutritional Science and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran


| Aghil Esmaeili-Bandboni
Department of Medical Genetics, School of Medicine, Guilan University of Medical Science, Rasht, Iran. Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Science, Rasht, Iran


| Mohammad Reza Emami
Department of Clinical Nutrition, School of Nutritional Science and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran


| Fatemeh Naeini
Department of Clinical Nutrition, School of Nutritional Science and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran


| Meysam Zarezadeh
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran


| Mohammad Hassan Javanbakht
Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_18598.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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