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Avicenna Journal of Phytomedicine، جلد ۱۱، شماره ۶، صفحات ۶۱۰-۶۲۱
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عنوان انگلیسی Neuroprotective effects of Pinus eldarica in a mouse model of pentylenetetrazole-induced seizures
چکیده انگلیسی مقاله Objective: Oxidative stress has pernicious effects on the brain. Pinus eldarica has antioxidant properties. We explored neuroprotective effect of P. eldarica against pentylenetetrazole (PTZ)-induced seizures.Materials and Methods: Male mice (BALB/c) were grouped as control, PTZ, Soxhlet (Sox) 100, Sox 200, Macerated (Mac) 100 and Mac 200 groups. Sox and Mac extracts (100 and 200 mg/kg) were injected during 7 days. Delay in onset of minimal clonic seizure (MCS) and generalized tonic- clonic seizure (GTCS) was measured. Number of dark neurons (DN) and levels of oxidative stress indicators in the hippocampus were evaluated.Results: Onset of MCS and GTCS was later in groups treated with the extracts than the PTZ group (p< 0.01 and p< 0.001). Number of DN in the hippocampus in the PTZ group was higher than the control group (p< 0.001) while in the extract groups, was lower than the PTZ group (p< 0.05, p< 0.01 and p< 0.001). MDA level was higher whereas total thiol level and activity of SOD and CAT were lower (p< 0.001) in the PTZ group than the control group. MDA level in the Sox 100 (p< 0.01), Sox 200 (p< 0.001) and Mac 200 (p< 0.01) groups was less than the PTZ group. Total thiol level in the Sox 200 (p< 0.001), SOD in the Sox 100 (p< 0.05), Sox 200, and Mac 200 and CAT in the Sox 200 (p< 0.001) groups were higher than the PTZ group. Conclusion: P. eldarica prevented neuronal death and reduced seizures caused by PTZ via improving brain oxidative stress.
کلیدواژه‌های انگلیسی مقاله Pinus eldarica, Pentylenetetrazole, Oxidative stress, Dark neurons
نویسندگان مقاله | Somaieh Mansouri
Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Anatomy, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran


| Mahmoud Hosseini
Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Farimah Beheshti
Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran. Department of Physiology, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran


| Mohammad-Ali Sobhanifar
Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Hassan Rakhshandeh
Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Akbar Anaeigoudari
Department of Physiology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_18562.html
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نوع مقاله منتشر شده Original Research Article
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