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Avicenna Journal of Phytomedicine، جلد ۱۱، شماره ۱، صفحات ۳۲-۴۳
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی In vitro and in vivo activity of the essential oil and nanoemulsion of Cymbopogon flexuosus against Trichomonas gallinae
چکیده انگلیسی مقاله Objective: This study was done to evaluate the in vitro and in vivo effects of the essential oil (OE-CL) and nanoemulsion (N-CL) of Cymbopogon flexuosus against Trichomonas gallinae. Materials and Methods: In vitro assays were done with 106 parasites and OE-CL and N-CL in the concentrations: 110, 220, 330, 440, 550, 660, 770 and 880 µg/ml and four controls: CN (culture medium and trophozoites), MTZ (trophozoites plus 800 µg/ml of metronidazole), TW (trophozoites plus vehicles used for solubilization of derivatives (0.01% Tween) and NB (blank nanoemulsion 880 µg/ml). The in vivo assay was done in 35 quails (Coturnix coturnix) infected experimentally 4x104 mg/kg, were divided in seven groups (n=5): A (control–healthy), B (control infected), C (control TW 0.01%), D (NB 0.88 mg/kg), E (drug MTZ 25 mg/kg, F (OE-CL at 0.55 mg/kg ) and G (N-CL at 0.44 mg/kg), during 7 consecutive days. Results: The in vitro test showed that the OE-CL (550 μg/ml) and N-CL (440 μg/ml) concentrations reduced the trophozoites viability in 100%. In the in vivo test, the treatment with OE-CL was efficient on the 4th treatment day and the N-CL after the 3rd day, and the MTZ in the therapeutic concentration was efficient on the 7th day. Conclusion: It can be observed in this study that the lemon grass has natural potential antitrichomonal activity against T. gallinae in vitro and in vivo.
کلیدواژه‌های انگلیسی مقاله Phytotherapy, Nanotechnology, birds, protozoa, lemon grass
نویسندگان مقاله | Bruna Baccega
Department of Microbiology and Parasitology- Federal University of Pelotas, Pelotas, RS, Brazil


| Yan Islabão
Department of Microbiology and Parasitology- Federal University of Pelotas, Pelotas, RS, Brazil


| Alexia Mello
Department of Microbiology and Parasitology- Federal University of Pelotas, Pelotas, RS, Brazil


| Filipe Martins
Department of Microbiology and Parasitology- Federal University of Pelotas, Pelotas, RS, Brazil


| Carolina Santos
Department of Microbiology and Parasitology- Federal University of Pelotas, Pelotas, RS, Brazil


| Aline Ourique
Laboratory of Nanotechnology - Franciscan University, Santa Maria, RS, Brazil


| Samanta Gundel
Laboratory of Nanotechnology - Franciscan University, Santa Maria, RS, Brazil


| Marcia Macedo
Department of Microbiology and Parasitology- Federal University of Pelotas, Pelotas, RS, Brazil


| Élvia Vianna
Department of Microbiology and Parasitology- Federal University of Pelotas, Pelotas, RS, Brazil


| Nara Farias
Department of Microbiology and Parasitology- Federal University of Pelotas, Pelotas, RS, Brazil


| Camila Oliveira
Department of Microbiology and Parasitology- Federal University of Pelotas, Pelotas, RS, Brazil
نشانی اینترنتی https://ajp.mums.ac.ir/article_15662.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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