این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Avicenna Journal of Phytomedicine، جلد ۱۰، شماره ۵، صفحات ۴۴۸-۴۵۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Evaluation of phytochemical and pharmacological properties of seeds of Momordica charantia
چکیده انگلیسی مقاله Objective: The purpose of the current study was to investigate the in vivo (analgesic, antidiarrheal, neurological, and cytotoxic) and in vitro (antioxidant, antimicrobial, thrombolytic and anthelmintic) activity of different fractions of methanolic extract of Momordica charantia. Materials and Methods: The antioxidant property was evaluated by DPPH radical scavenging assay, while antimicrobial activity was examined against three Gram (+) and one Gram (-) bacteria. Thrombolytic and anthelmintic activities were evaluated by using human blood serum and by recording paralysis and death time in earthworm, respectively. Cytotoxic activity was investigated in brine shrimp nauplii. Analgesic and antidiarrheal activities were evaluated in Swiss albino mice and neurological effect was evaluated by open field and Elevated plus-maze test (EPM). Results: All fractions (n-hexane, carbon tetrachloride and chloroform) possess significant (p< 0.05) cytotoxic activity. In case of thrombolytic activity, the highest concentration of methanolic extract produced a remarkable percentage of clot lysis (46.12%). The concentration of 1000 μg/ml produced a significant antibacterial activity against Gram positive Staphylococcus aureus and Gram negative E. coli. Aqueous fraction at a dose of 400 mg/kg body weight, was found to show promising analgesic activity. In case of antidiarrheal and anthelmintic activity, plant extract showed dose-dependent activity. Methanolic extract and its fractions failed to produce any neurological effect in both methods. Conclusion: The overall results of the study tend to suggest that the methanolic extract and its fractions have promising pharmacological activities.
کلیدواژه‌های انگلیسی مقاله Momordica charantia, Seeds, In-vitro, In-vivo
نویسندگان مقاله | Sumyya Zahan
Department of Pharmacy, University of Chittagong, Chittagong-4331, Bangladesh


| Tajbiha-E- Mowla
Department of Pharmacy, Southern University, Chittagong, Bangladesh


| S.M. Naim Uddin
Department of Pharmacy University of Chittagong


| Mohammed Kamrul Hossain
Department of Botany, University of Chittagong, Chittagong-4331


| Afifa Binthe Mannan
Department of Genetic Engineering and Biotechnology, University of Chittagong, Chittagong-4331, Bangladesh


| Minhajur Rahman
Department of Botany, University of Chittagong, Chittagong-4331, Bangladesh


| Umay Chen
Department of Pharmacy, University of Chittagong, Chittagong-4331, Bangladesh


| Tanoy Mazumder
Department of Pharmacy, Noakhali Science and Technology University, Sonapur-3814, Noakhali, Bangladesh


| A.H.M. Mazbah Uddin
Department of Pharmacy, Mawlana Bhashani Science and Technology University, Santosh-1902, Tangail


| Sayema Arefin
Department of Pharmacy, Mawlana Bhashani Science and Technology University, Santosh-1902, Tangail


| Md. Saddam Hussain
Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814,Bangladesh
نشانی اینترنتی https://ajp.mums.ac.ir/article_14503.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Research Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات