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World Journal of Plastic Surgery، جلد ۱۱، شماره ۱، صفحات ۳۰-۳۷
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عنوان انگلیسی Effects of Botulinum Toxin Type A on the Axial Skin Flap Survival
چکیده انگلیسی مقاله BACKGROUND A suitable pharmacological substitute for the well-established surgical delay technique for axial skin flaps regarding increasing viability is elusive. We aimed to evaluate the effects of botulinum toxin type A (BTA) on the axial skin flap survival in a rat model. METHODS The present controlled experimental study was performed in Kerman University of Medical Science, Kermanshah, Iran during 2016-2017 on three groups of rats. Group 1 (control group) had no preconditioning while Groups 2 and 3 were preconditioned by the intradermal injection of normal saline (0.5 ml) in the cephalic end of the skin flap and the injection of the BTA (1.6 units Neuronex) reconstituted in normal saline, respectively. Two weeks after this intervention in each group, the flap was raised and kept in situ and a biopsy was simultaneously taken for evaluating neoangiogenesis, followed by evaluating flap necrosis after two weeks of following-up by photography. RESULTS Although BTA induced angiogenesis significantly, it failed to reduce the area of necrosis compared to the other groups. CONCLUSION BTA was effective in increasing angiogenesis in the axial skin flap although it was unable to reduce necrosis.
کلیدواژه‌های انگلیسی مقاله Botulinum toxin type A, Necrosis, Survival, Axial, Rat, Skin flap
نویسندگان مقاله | Maryam Iranpour
1. Department of Pathology, Pathology and Stem Cell Research Center, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran


| Ali Khodarahmi
2. Department of Surgery, Pathology and Stem Cell Research Center, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran


| Maryam Beigi
3. Pathology and Stem Cell Research Center, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran


| Omid Azari
4. Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman


| Soraya Shahrokh Shahraki
5. Department of Plastic Surgery, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://wjps.ir/browse.php?a_code=A-10-51-6&slc_lang=en&sid=1
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