این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
World Journal of Plastic Surgery، جلد ۱۰، شماره ۲، صفحات ۶۷-۷۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Evaluation of Acellular Dermal Matrix (ADM) as a Scaf-fold for Adipose-Derived Stem Cell Transfer in the Rat Model
چکیده انگلیسی مقاله BACKGROUND This study was designed for the evaluation of Acellular Dermal Matrix (ADM) as a scaffold for adipose-derived stem cell transferring in the rat model. METHODS This experimental study was done in the Burn Research Center of Iran University of Medical Sciences and Bonyakhteh Research Center, Tehran, Iran according to the standards of laboratory animals. Overall, 26 healthy Sprague-Dawley rats were used. Two of them were used to prepare ADM. In group one, the first wound on each, rat was spread with the mixture of fibrin gel and autologous stem cell. Only the stem cells combined with fibrinogen were spread on the other wound. In group two, the first wound on each rat was covered only with ADM, and the second wound was covered with gauze Vaseline. To perform sampling we used observation and photography at 7-30 days. Overall, 48 samples were taken of all the rats using skin punch biopsy on the 30th day for histopathology evaluation. RESULTS There were significant differences in each group; however, the difference between different groups on days was not significant. In pathology, epithelialization, vascularization, the amount of collagen, collagen arrangement, the number of fibroblasts, and inflammation indices were investigated. The total score in each group was used for analysis. In statistical analysis, there was no pathology score difference among groups. CONCLUSION Using stem cells with or without ADM could not enhance the process of wound healing or improve pathology indices.
کلیدواژه‌های انگلیسی مقاله Stem cell, Tissue engineering, Acellular Dermis
نویسندگان مقاله | Maryam Jahanian
Burn Research Center, Hazrat Fatima Hospital, Rehabilitation Research Center, School of Rehabilitation Sci-ences, Iran University of Medical Sciences, Tehran, Iran.


| Sara Hoseini
Burn Research Center, Rajaie Cardi-ovascular Medical and Research Cen-ter, Iran University of Medical Sci-ences, Tehran, Iran


| Amir Atashi
Stem Cell and Tissue Engineering Research Center, Shahroud Universi-ty of Medical Sciences, Shahroud, Iran.


| Mohsen Saberi
Community Medicine, Quran and Hadis Research Center, Faculty of Medicine, Baqiyatallah University of Medical Sciences Tehran, Iran.


| Seyyed Aboozar Hoseini
Burn Research Center, Hazrat Fatima Hospital, Iran University of Medical Sciences, Tehran, Iran.


| Kambiz Mozaffari
Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.


| Mohammad Javad Fatemi
Department of Plastic & Reconstruc-tive Surgery, Burn Research Center, Hazrat Fatima Hospital Iran Universi-ty of Medical Sciences, Tehran, Iran.
نشانی اینترنتی http://wjps.ir/browse.php?a_code=A-10-270-3&slc_lang=en&sid=1
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده تخصصی
نوع مقاله منتشر شده مقالات اصیل
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات