این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
World Journal of Plastic Surgery، جلد ۱۰، شماره ۲، صفحات ۷۶-۸۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The Role of Recombinant Fibroblast Growth Factor 1 in Enhancing the Angiogenesis in Random Cutaneous Flaps in Animal Model of Rat
چکیده انگلیسی مقاله BACKGROUND Randomized skin flaps have been used as a basic treatment modality for covering skin defects for a long time but they have always been in the risk of an inherent ischemia. Fibroblast growth factor 1 is a known angiogenic factor in in vitro studies which has shown conflicting results in in vivo investigation. We aimed to determine the effect of recombinant fibroblast growth factor on the angiogenesis rate of random cutaneous flap in animal model of rats. METHODS This experimental study was conducted on 24 adult male rats randomized to 2 groups. In the first group FGF1 was injected subdermally in equally divided doses and distances of random flap surface in days 1, 3 and 5. In second group, normal saline was injected as control. Flap surgery was done on day 21 after first injection. The extent of necrosis and angiogenesis (mean vessel density) were assessed in day 14 after surgery. Results The mean percentage of clinically apparent necrosis was 35.2% (±10.5) in intervention (FGF1) group and 38.1% (±8.7) in control (normal saline), re-spectively. Mean vessel density was 86.20±5.6/mm2 in control group and 90.17±5.5/mm2 in intervention group, which showed no statistically signifi-cant difference. CONCLUSION Mean vessel density and mean percentage of clinically apparent necrosis area were similar in 2 groups of rats with random cutaneous flaps receiving FGF1 or normal saline.
کلیدواژه‌های انگلیسی مقاله Fibroblast growth factor 1, Angiogenesis, Random skin flap
نویسندگان مقاله | Hossein Akbari
Department of Plastic and Recon-structive Surgery, School of Medi-cine, Iran University of Medical Sci-ences (IUMS), Tehran, Iran


| Mehdi Ahmadi
Department of Plastic and Recon-structive Surgery, School of Medi-cine, Iran University of Medical Sci-ences (IUMS), Tehran, Iran


| Mohammad Javad Fatemi
Department of Plastic and Recon-structive Surgery, School of Medi-cine, Iran University of Medical Sci-ences (IUMS), Tehran, Iran


| Ali Foroutan
Department of Plastic and Recon-structive Surgery, School of Medi-cine, Iran University of Medical Sci-ences (IUMS), Tehran, Iran


| Peyman Akbari
Department of Plastic and Recon-structive Surgery, School of Medi-cine, Iran University of Medical Sci-ences (IUMS), Tehran, Iran


| Hossein Bagheri
Department of Anesthesiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.


| Majid Golkar
Department of Parasitology, Pasteur Institute of Iran, Tehran, Iran
نشانی اینترنتی http://wjps.ir/browse.php?a_code=A-10-270-2&slc_lang=en&sid=1
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده تخصصی
نوع مقاله منتشر شده مقالات اصیل
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات