این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
World Journal of Plastic Surgery، جلد ۱۰، شماره ۲، صفحات ۸۲-۸۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Comparative Experimental Study of Dermal Stability: Acellular Dermal Matrix versus Crayopreserved Dermis
چکیده انگلیسی مقاله BACKGROUND Given the potential usefulness of Acellular Dermal Matrices (ADM) for wound healing, we aimed to evaluate the stability, histological characteristics, and effectiveness of ADM compared with cryopreserved dermis (CPD) in rat models. METHODS This experimental study was conducted in the Department of Surgery, Isfahan University of Medical Sciences, Isfahan, Iran, from January to March 2015. The prepared ADM and CPD were transplanted to the full-thickness skin defects on the back of Sprague-Dawley rats. Forty-five days after grafting, the tissues were harvested for histological examination. These two types of the dermis' quality and stability were compared with consideration of the following factors; inflammation, fibroblasts migration, vascularization, collagen formation, capsule formation, and microabscess formation. RESULTS From 19 selected rates, nine received CPD, and ten were treated with ADM. After transplantation, the mean (SD) weight of ADM and CPD grafts were 1.74 (0.07) and 1.45 (0.77), respectively (P< 0.001). The frequency of inflammation was significantly higher in CPD grafts (P< 0.01). Higher grades of collagen organization, fibroblast spreading, and vascularization were more frequent in ADM grafts (P< 0.01). The frequency of capsule and microabscesses formation was not significantly different between studied groups. CONCLUSION ADM have a superior effect than CPD in the wound healing process. Both samples had a similar effect in capsule and microabscesses formation and higher costs of ADM preparation. According to the physicians' decision and evaluation of the process's cost-effectiveness, CPD could be appropriately used as an alternative to ADM.
کلیدواژه‌های انگلیسی مقاله Inflammation, Acellular dermal matrix, Crayopreserved dermis, Collagen, Fibroblasts, Pathological neovascularization
نویسندگان مقاله | Mahmood Omranifard
Department of Plastic Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


| Mehdi Rasti Ardakani
Department of Plastic Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


| Hossein Abdali
Department of Plastic Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


| Pejman Mortazavi
Department of Pathology, School of Specialize Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran


| Saeed Hoseini
Department of Pathology, School of Specialize Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran


| Mohammad Ali Hoghoughi
Burn and Wound Healing Research Center, Shiraz University of Medical Science, Shiraz, Iran
نشانی اینترنتی http://wjps.ir/browse.php?a_code=A-10-466-21&slc_lang=en&sid=1
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده تخصصی
نوع مقاله منتشر شده مقالات اصیل
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات