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Journal of Cardio-Thoracic Medicine، جلد ۹، شماره ۴، صفحات ۸۷۸-۸۸۳
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عنوان انگلیسی Inflammatory and Tissue Damage Biomarkers Progression as Mortality Prognosis in Patients with Covid-19 Disease
چکیده انگلیسی مقاله Introduction: Metabolic and inflammatory disorders are widely described in COVID-19 disease by SARS-CoV-2, especially in advanced gravity stages, nevertheless, the increase in inflammatory and tissue damage biomarkers could identify patients with higher mortality risk since early disease stages.Material and Method: A retrospective Cohort study was performed to evaluate the progression pattern and mortality risk of proinflammatory (Ferritin and IL-6) and damage tissue biomarkers seric levels (LDH, CPK, CPK-MB and TnIc) since the beginning of the disease to end outcome considered, in this study, as death or recoveryResults: We evaluated 120 patients with mean age 51±10 years. The CAT study showed in all patients bilateral polished glass lung lesions. The inflammatory and seric tissue injured biomarkers were significantly higher since the beginning of the hospitalization in patients who died compared with patients that survived (p = 0.01). The myocardial injury biomarkers (CPK-MB and TnIc) were significantly higher in severe gravity stages of deceased patients compared to patients who survived (p = 0.001 and 0.003 respectively) with a global mortality of 38.3% (n = 48). The mortality risk was extremely elevated (RR> 10) when inflammatory and tissue injury biomarkers showed seric levels 2 folds above normal values, showing survival of < 60% after tenth day since the beginning disease.Conclusion: Since the beginning of COVID-19 disease by SARS CoV2 virus, patients show serum elevation in ferritin, LDH and CPK. This seric values were associated with higher mortality risk, when elevated 2 folds above normal values.
کلیدواژه‌های انگلیسی مقاله SARS-CoV-2, COVID-19, inflammatory Biomarkers, Tissue injury
نویسندگان مقاله | Monica Escamilla Tilch
Science Research Doctor, Biomedical Research Department, CMN 20 de Noviembre ISSSTE, México City.


| Lourdes López Dawn
Cardiothoracic Surgeon, Cardiovascular Department, CMN 20 de Noviembre ISSSTE, México City.


| Adriana Balderrama
Endocrinologist, Endocrinology Department, CMN 20 de Noviembre ISSSTE, México City.


| Francisco Ramírez Bernal
Intensive Care Physician, Intensive Therapy Department, CMN 20 de Noviembre ISSSTE, México City.


| Brigney Aceves Poveda
Intensive Care Physician, Intensive Therapy Department, CMN 20 de Noviembre ISSSTE, México City.


| Guillermo Díaz Quiroz
Cardiothoracic Surgeon, Cardiovascular Department, CMN 20 de Noviembre ISSSTE, México City.


| Alberto De la Vega
Intensive Care Physician, Intensive Therapy Department, CMN 20 de Noviembre ISSSTE, México City.


| Paul Mondragón-Terán
Bio-medical Engineer, Research Coordination, CMN 20 de Noviembre ISSSTE, México City.


| José Aceves Chimal
Cardiothoracic Surgeon, Cardiovascular Department, CMN 20 de Noviembre ISSSTE, México City.
نشانی اینترنتی https://jctm.mums.ac.ir/article_19206.html
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