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مجله حکیم سیداسماعیل جرجانی، جلد ۱۰، شماره ۱، صفحات ۴۱-۵۵
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عنوان انگلیسی Adenosine Receptor Signaling in Diseases with Focus on Cancer
چکیده انگلیسی مقاله Various investigation has shown the magnitude role of adenosine receptors in cancer development. The A1, A2A, A2B, and A3 G-protein-coupled cell surface Adenosine Receptors (ARs) are found to be upregulated in many types of cancers. The adenosine receptor function has been affected by specific ligands such as agonists and/or antagonists regulated cancer (Neoplasms) cells proliferation via signaling pathways. Adenosine not only is an important intermediate metabolite but also acts as the essential ligand of adenosine receptors in physiological and pathological conditions. Furthermore, many studies have shown that adenosine receptors expression has increased in many types of cancer. In this review, we first describe adenosine's role in physiological condition and in cancer development. We further, discuss the type of adenosine receptors, distribution, expression, and their roles in cancer.
کلیدواژه‌های انگلیسی مقاله Adenosine,Receptors Purinergic P1,Neoplasms
نویسندگان مقاله | Mahmmod Poorjam
Metabolic disorder research center, Golestan University if Medical Sciences, Gorgan, Iran/Department of Biochemistry and Biophysics, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran


| zeinab mohammadi
Metabolic disorder research center, Golestan University if Medical Sciences, Gorgan, Iran/Department of Biochemistry and Biophysics, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran


| Seyyed Mehdi Jafari
Golestan University of Metabolic disorder research center, Golestan University if Medical Sciences, Gorgan, Iran/Department of Biochemistry and Biophysics, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran sciences
نشانی اینترنتی http://goums.ac.ir/jorjanijournal/browse.php?a_code=A-10-522-1&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده علوم پایه پزشکی
نوع مقاله منتشر شده مروری
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