این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
مجله حکیم سیداسماعیل جرجانی، جلد ۹، شماره ۳، صفحات ۱۳-۲۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The Simultaneous Effect of Linum Usitatissimum Supplementation and Aerobic Training on 6-Methylguanine and ATP in the Endothelial Aorta and Heart Tissues in Rats Poisoned with H2O2
چکیده انگلیسی مقاله Background and Objective: As a high-energy demanding tissue, the heart is exposed to a high level of ROS molecules such as H2O2, leading to cardiovascular disorders through damaging macromolecules such as DNA and disrupting ATP production. Hence, this study aimed to investigate the simultaneous effect of aerobic exercise (Ae) and Linum Usitatissimum (Lu) supplementation on DNA damage and ATP synthesis in heart and aorta endothelial tissues in rats poisoned with hydrogen peroxide (H2O2). Material and Methods: 56 male Wistar Albino rats were randomly divided into 7 groups, including HC (Healthy Control), TC (Toxicated Control), Lu1 (Received 5 mg/kg of Lu), Lu2 (Received 10 mg/kg of Lu), Ae (Received only Aerobic Exercise), Ae Lu1, and Ae Lu2. Then, all groups got poisoned by H2O2 except HC. Next, they received Linum Usitatissimum (Lu) supplementation and Low-Intensity Interval Training (LIIT). Finally, 24h after the last treatment session, the level of 6-methylguanine (6MG) and ATP were measured via the ELISA technique in cardiovascular tissue. Results: The findings determined that Lu supplementation and Ae significantly diminish the 6-methyl guanine level in endothelial (F=111.3, p=0.0008, ƞ=0.9823) and heart cells (F=147.9, p=0.0005, ƞ=0.9867). Also, the ATP level was increased significantly in endothelial (F=342.6, p=0.0003, ƞ=0.9942) and heart cells (F=135.1, p=0.0013, ƞ=0.9854). However, no considerable changes were found for both factors in groups who received Ae or Lu singularly. Conclusion: The study showed that concurrent administration of Lu and Ae could exert dynamic cardioprotective properties through their antioxidant effects.
کلیدواژه‌های انگلیسی مقاله H2O2 Toxicity,Mitochondrial,Cardiovascular Diseases,Herbal Medicine,Rehabilitation,Exercise
نویسندگان مقاله | Seyed Mostafa rezaei
Ph.D. student, Department of Physical Education and Sport Sciences, Mahallat Branch, Islamic Azad University. Mahallat, Iran


| Bahram Abedi
Professor, Department of Physical Education and Sport Sciences, Mahallat Branch, Islamic Azad University. Mahallat, Iran


| Hoseyn Fatolahi
Assistant Professor, Department of Physical Education, Pardis Branch, Islamic Azad University, Pardis, Iran
نشانی اینترنتی http://goums.ac.ir/jorjanijournal/browse.php?a_code=A-10-821-2&slc_lang=en&sid=1
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده بهداشت
نوع مقاله منتشر شده تحقیقی
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات