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مجله حکیم سیداسماعیل جرجانی، جلد ۹، شماره ۳، صفحات ۶۱-۶۸
عنوان فارسی
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عنوان انگلیسی Detection of Hb Bart's and Hb H Diseases Caused by -α3.7 Prevalent Deletion Using Capillary Electrophoresis in Ardabil Province
چکیده انگلیسی مقاله Background and Objective: Alpha-thalassemia (α-thal) appears to be the most common monogenic disorder worldwide. The diagnosis of α-thalassemia depends on the detection of Hemoglobin Bart (Hb Bart's) in newborns, which indicates one or more defective or absent α-globin genes. In addition, in patients with Hemoglobin H (Hb H), the Hb H range usually varies between 7-10 g / dL. Therefore, tracking Hb Bart's and Hb H can be useful in diagnosing thalassemia α. This study was performed to evaluate Hb Bart's and Hb H in infants with α thalassemia in Ardabil province, northwestern Iran. Material and Methods: In this cross-sectional descriptive study, 33 infants with alpha thalassemia mutation, including infants born in Ardabil province, Iran in the years 2020 to 2019. Hemoglobin analysis was performed by capillary electrophoresis system. Results: Hb H and Hb Bart's were detected in only two cases (6%) and three cases (9%). In this study, only 5 patients (15.15) were observable by detection of Hb Bart's and Hb H levels by electrophoresis. In cases of Hb Bart disease, -α3.7 was the most common genotype. Therefore, most infants with alpha thalassemia were lost when electrophoresis alone was used. Conclusion: This study showed that molecular analysis of Hb Bart's newborns is necessary to confirm α-thalassemia. Capillary electrophoresis is a way to prevent the diagnosis of rare Hb H and Bart's disease.
کلیدواژه‌های انگلیسی مقاله alpha-Thalassemia,hemoglobin Bart&apos,s,Hemoglobin H,Electrophoresis Capillary
نویسندگان مقاله | Fathi Afshin
Pediatric Hematology and Oncology Department, Ardabil University of Medical Science, Ardabil, Iran


| Mehdi Valizadeh
Unit of Genomics Research, Digestive Diseases Research Center, Ardabil University of Medical Sciences, Ardabil, Iran


| Rouhallah Moradpoor
Center for Cell Pathology Research, Department of Life Science, Khazar University, Baku, Azerbaijan


| Mahshid Damandan
Center for Cell Pathology Research, Department of Life Science, Khazar University, Baku, Azerbaijan


| Firouz Amani
Department of Community Medicine, Ardabil University of Medical Science, Ardabil, Iran
نشانی اینترنتی http://goums.ac.ir/jorjanijournal/browse.php?a_code=A-10-754-3&slc_lang=en&sid=1
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