این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Journal of Health Sciences and Surveillance System، جلد ۹، شماره ۴، صفحات ۲۵۷-۲۶۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Permethrin-associated kdr Mutations through Molecular Analysis of Human Head Lice (Phthiraptera: Pediculidae) Populations in School Children in the South of Iran
چکیده انگلیسی مقاله Background:Human head lice is one of the most invincible neglected skin diseases. The use of pyrethroid insecticides is a standard method of treating the disease, which leads to lice population resistance in the long run. The main aim of the current survey was to screen the biomarkers of permethrin-associated kdr (knockdown resistance) point mutations through molecular analysis of the human head lice populations in primary school children in the south of Iran. Methods: In an experimental study, Field-collected head lice from infested students were fixed in ethanol, identified using valid taxonomic keys, and processed by PCR for kdr mutant studies. Sequencing partial voltage-sensitive sodium channel gene in different head lice populations was subsequently implemented and compared with the permethrin-resistant diamondback moth, Plutella xylostella (Lepidoptera: Plutellidae) as the gold standard. Results:Human head lice appeared to reflect kdr point mutations in specimens from the city of Shiraz. At least three amino acid mutations at designated sites of D820E, L840F, and N874G, corresponding to replacements of aspartic acid to glutamic acid, leucine to phenylalanine, and asparagine to glycine, are clear in this representative population, respectively. At the same time, only L840F is reported as a new mutant in this survey. Conclusion: The ongoing treatment of head lice infested in school children harboring kdr-mutated or permethrin-resistant mutants in Shiraz is risky, illogical, and contrary to the One Health initiative of the World Health Organization. Health executives should thus immediately take the indispensable steps to prohibit further procurement of permethrin.
کلیدواژه‌های انگلیسی مقاله Insecticide, Iran, Pediculus humanus, Permethrin, Voltage-sensitive sodium channel
نویسندگان مقاله Saeedeh Ebrahimi |
Department of Biology and Control of Disease Vectors (Medical Entomology), School of Health, Shiraz University of Medical Sciences, Shiraz, Iran

Marzieh Shahriari-Namadi |
Department of Biology and Control of Disease Vectors (Medical Entomology), School of Health, Shiraz University of Medical Sciences, Shiraz, Iran

Saeed Shahabi |
Department of Biology and Control of Disease Vectors (Medical Entomology), School of Health, Shiraz University of Medical Sciences, Shiraz, Iran

Mohammad Djaefar Moemenbellah-Fard |
Department of Biology and Control of Disease Vectors (Medical Entomology), School of Health, Shiraz University of Medical Sciences, Shiraz, Iran

Hamzeh Alipour |
Research Center for Health Sciences, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran

نشانی اینترنتی https://jhsss.sums.ac.ir/article_47895_6c9485587fce7001d534c140ffd1cf06.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات