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The Archives of Bone and Joint Surgery، جلد ۱۰، شماره ۳، صفحات ۲۲۹-۲۴۴
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عنوان انگلیسی Biochemical Aspects of Scaffolds for Cartilage Tissue Engineering; from Basic Science to Regenerative Medicine
چکیده انگلیسی مقاله Chondral defects are frequent and important causes of pain and disability. Cartilage has limited self-repair and regeneration capacity. The ideal approach for articular cartilage defects is the regeneration of hyaline cartilage with sustainable symptom-free constructs. Tissue engineering provides new strategies for the regeneration of functional cartilage tissue through optimized scaffolds with architectural, mechanical, and biochemical properties similar to the native cartilage tissue. In this review, the basic science of cartilage structure, interactions between proteins, stem cells, as well as biomaterials, scaffold characteristics and fabrication methods, as well as current and potential therapies in regenerative medicine will be discussed mostly from a biochemical point of view. Furthermore, the recent trends in scaffold-based therapies and supplementary factors in cartilage tissue engineering will be considered. Level of evidence: I
کلیدواژه‌های انگلیسی مقاله biochemical, cartilage, cartilage regeneration, Scaffold, Tissue engineering
نویسندگان مقاله | Davood Yari
1 Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. 2 Department of Clinical Biochemistry, Babol University of Medical Sciences, Babol, Iran 3 Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Mohammad H. Ebrahimzadeh
Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Jebrail Movaffagh
Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| Azadeh Shahroodi
Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| Moein Shirzad
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. 2 Department of Clinical Biochemistry, Babol University of Medical Sciences, Babol, Iran


| Durdi Qujeq
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. 2 Department of Clinical Biochemistry, Babol University of Medical Sciences, Babol, Iran


| Ali Moradi
Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی https://abjs.mums.ac.ir/article_19671.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده CURRENT CONCEPTS REVIEW
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