| چکیده انگلیسی مقاله |
Background: Platelet-rich plasma (PRP), an autologous source of growth factors, and hyaluronic acid (HA) are amongthe minimally invasive treatments for knee osteoarthritis (OA). This trial was designed to compare the effectiveness ofintra-articular injection of PRP with HA (as one of the standard treatments) on mild to moderate knee OA.Methods: In this phase I open-label clinical trial, 10 patients underwent intra-articular PRP injection and 10 othersreceived HA injection. At baseline (pre-injection) visit and 1, 3, 6, and 12 months post-injection, clinical assessmentswere performed using visual analogue scale (VAS) and Knee injury and Osteoarthritis Outcome Score (KOOS)questionnaire. Physical examinations of the knee, including crepitation and range of motion (ROM) were performed ateach visit. The follow-up responses were compared with the baseline visit.Results: The PRP treatment was ascertained to be safe and caused no adverse effects. Significant improvementsin the majority of KOOS subscales and VAS were found throughout the entire 12-month follow-up, following the PRp injections. HA injection, however, caused only one month significant improvement in the majority of patient-reportedoutcomes. In the majority of visits, the extent of improvements in the scores of KOOS subscales, as well as the extentof reduction in VAS were significantly greater in PRP recipients, compared to HA recipients. The ROM in both groupsslightly increased after interventions. The frequency of coarse crepitation, which was detected in 100% of the patientsin both groups at the baseline visit, decreased significantly to fine crepitation at the first follow-up visit in 80% and 40%of the PRP and HA recipients, respectively.Conclusion: Intra-articular injection of PRP or HA alleviates symptoms and pain and improves functionality and physicalexaminations in patients with knee OA. However, PRP therapy produces greater and longer-lasting improvements inmost of the outcome parameters compared to HA.Level of evidence: II |
| نویسندگان مقاله |
| Sara Jalali Jivan
Center of Excellence for Stem Cell Research and
Regenerative Medicine, Mashhad University of Medical
Sciences, Mashhad, Iran- Rheumatology Division, Department of Internal
Medicine, School of Medicine, Ardabil University of
Medical Sciences, Ardabil, Iran
| Seyed Monzavi
Center of Excellence for Stem Cell Research and
Regenerative Medicine, Mashhad University of Medical
Sciences, Mashhad, Iran-Department of Tissue Engineering and Applied Cell
Sciences, School of Advanced Technologies in Medicine,
Tehran University of Medical Sciences, Tehran, Iran
| Bita Zargaran
Center of Excellence for Stem Cell Research and
Regenerative Medicine, Mashhad University of Medical
Sciences, Mashhad, Iran
| Daryoush Hamidi Alamdari
Center of Excellence for Stem Cell Research and
Regenerative Medicine, Mashhad University of Medical
Sciences, Mashhad, Iran- Department of Clinical Biochemistry, Biochemistry
and Nutrition Research Center, School of Medicine,
Mashhad University of Medical Sciences, Mashhad, Iran
| Jalil Tavakol Afshari
Center of Excellence for Stem Cell Research and
Regenerative Medicine, Mashhad University of Medical
Sciences, Mashhad, Iran- Immunology Research Center, Mashhad University of
Medical Sciences, Mashhad, Iran
| Ali Etemad-Rezaie
Division of Orthopaedic Surgery, Department of
Surgery, Faculty of Medicine, University of Toronto,
Toronto, ON, Canada
| Tayebeh Asadi Sakhmaresi
Center of Excellence for Stem Cell Research and
Regenerative Medicine, Mashhad University of Medical
Sciences, Mashhad, Iran-Department of Internal Medicine, School of Medicine,
Mashhad University of Medical Sciences, Mashhad, Iran
- Golestan Rheumatology Research Center, Golestan
University of Medical Sciences, Gorgan, Iran
| Zhaleh Shariati-Sarabi
Center of Excellence for Stem Cell Research and
Regenerative Medicine, Mashhad University of Medical
Sciences, Mashhad, Iran-Department of Internal Medicine, School of Medicine,
|