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Middle East Journal of Digestive Diseases، جلد ۱۳، شماره ۴، صفحات ۲۷۸-۲۹۳
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عنوان انگلیسی Colonic Mucosal Infiltration of IgG4 Plasma Cells and Ulcerative Colitis: Determinant of Presence, Activity, Extension, and Duration of Disease
چکیده انگلیسی مقاله BACKGROUND: Infiltration of IgG4 positive plasma cells has been detected in the colonic mucosa of patients with ulcerative colitis (UC). The aim of the study was to investigate the association between colonic mucosal infiltration of IgG4 plasma cells and the presence, activity, extension, and duration of UC. METHODS: In this case-control study (2009-2014), 102 subjects (84 with UC/18 controls) were enrolled. Clinical records and rectosigmoid biopsies of UC patients were selected, and biopsies were stained with IgG4 monoclonal antibodies. IgG4 positive plasma cells were counted by a single pathologist. RESULTS: Amongst 84 patients with UC, 73.8% had UC without primary sclerosing cholangitis (PSC), and 26.2% had UC with PSC. IgG4 plasma cells were seen in 35 (41.7%) patients with UC and 0% of controls ( p =0.001). The mean amount of IgG4 containing plasma cells was significantly different between active and inactive patients with UC, although it was not significantly different between UC patients with and without PSC. The presence of IgG4 infiltration was significantly associated with the extension and duration of the disease. Furthermore, IgG4 count had a sensitivity/specificity of 78.6%/83.3% for the diagnosis of UC. CONCLUSIONS: Our study revealed the diagnostic role of IgG4 plasma cells in the colonic mucosa of patients with UC and its association with activity, extension, and duration of disease.
کلیدواژه‌های انگلیسی مقاله Ulcerative colitis, IgG4 plasma cells, Duration of disease, Disease activity, Extension of Disease, Primary Sclerosing Cholangitis
نویسندگان مقاله | Foroogh Alborzi
Professor of Gastroenterology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran


| Nasser Ebrahimi Daryani
Internal Medicine Resident, Internal Medicine Department, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran


| Tina Deihim
Researcher, Iran University of Medical Sciences, Tehran, Iran


| Zahra Azizi
Pathologist, Associate Professor of Tehran University of Medical Sciences, Tehran, Iran


| Farid Azmoudeh Ardalan
Assistant professor of gastroenterology, Isfahan University of Medical Sciences, Isfahan, Iran


| Azam Teimouri
Assistant Professor of Gastroenterology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran


| Reza Taslimi
Associate Professor of Gastroenterology, Tehran University of Medical Sciences, Tehran, Iran


| Nader Roshan
Assistant Professor of Gastroenterology, Ilam University of Medical Sciences, Ilam, Iran


| Masood Mami
Resident of Community Medicine, Bushehr University of Medical Sciences, Bushehr, Iran


| Monirsadat Mirzade


| Najme Aletaha


نشانی اینترنتی http://mejdd.org/index.php/mejdd/article/view/2403
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi) 10.15171/middle east j di.v13i4.2403
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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