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Middle East Journal of Digestive Diseases، جلد ۱۳، شماره ۴، صفحات ۳۲۱-۳۲۷
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Epidemiological and Clinical Factors Associated with Spontaneous Clearance of Hepatitis C Virus
چکیده انگلیسی مقاله BACKGROUND: The risk of chronicity is high after acute hepatitis C. The infection remains limited and spontaneously resolves in an average of 30% of subjects. Such subjects are considered recovered and do not require any medical care. This study aims to evaluate the epidemiological and clinical factors associated with spontaneous viral clearance. METHODS: We conducted a descriptive retrospective study on patients’ files managed for a positive hepatitis C serology who benefited from the research of serum viral RNA by molecular biology. RESULTS: The study collected 429 usable files. The mean age of the patients was 50.21 years, and the sex ratio was 0.98. Spontaneous viral clearance was estimated at 17.2%. The univariate analysis showed that clearance was significantly greater in subjects under the age of 50 years, patients without type 2 diabetes, patients co-infected with hepatitis B virus, patients with transfusion, and those diagnosed fortuitously. Multivariate analysis confirmed the relationship between diabetes and the circumstances of the diagnosis. The relationship in the case of hepatitis B co-infection was very close to the statistical significance level ( p =0.055). CONCLUSION: The presence of hepatitis B co-infection in patients with positive hepatitis C serology predicts a high probability of having spontaneous clearance. However, advanced age and the existence of a history of blood transfusion, type 2 diabetes or suggestive signs of liver damage are associated with persistent viremia.
کلیدواژه‌های انگلیسی مقاله Hepatitis C virus,Spontaneous clearance,Diabetes,Diagnostic circumstances,Hepatitis B co-infection
نویسندگان مقاله | Wahiba Guenifi
University Ferhat Abbas, Setif1, Algeria


| Abdelkader Gasmi
University Ferhat Abbas, Setif1, Algeria


| Abdelmadjid Lacheheb


نشانی اینترنتی http://mejdd.org/index.php/mejdd/article/view/2343
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi) 10.15171/middle east j di.v13i4.2343
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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