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Middle East Journal of Digestive Diseases، جلد ۱۳، شماره ۴، صفحات ۳۳۳-۳۳۸
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عنوان انگلیسی Differences in duodenal mast cell and eosinophil counts between patients with functional dyspepsia and healthy people
چکیده انگلیسی مقاله BACKGROUND: Functional dyspepsia is a common, troubling, and usually chronic disorder. Although the merit of using pathological assays has not been confirmed, medications affecting eosinophils may result in some improvements. Disseminated distribution of mast cells may also be an essential factor. Given the probable associations and lack of evidenced-based data, this study was conducted to comparatively investigate the number of eosinophils and mast cells in the duodenum in functional dyspepsia patients and healthy controls. METHODS : In this case-control study, 150 consecutive subjects in Kerman, Iran, were enrolled in 2015 and 2016; the subjects consisted of 100 patients with functional dyspepsia and 50 asymptomatic healthy controls. Samples from the two groups were compared for the number of eosinophils, mast cells, and Helicobacter pylori presence by grasp biopsy. RESULTS: The mean number of mast cells significantly differed between the groups (P = 0.001), but the eosinophil count was similar ( p > 0.05). Female gender, no opioid use, and H . pylori may increase mast cell count ( p < 0.05). CONCLUSIONS: Overall, the mast cell count was significantly different between people with functional dyspepsia and people without it, but the eosinophil count in the two groups was similar.
کلیدواژه‌های انگلیسی مقاله functional dyspepsia, inflammation, duodenum
نویسندگان مقاله | Mohammad Mahdi Hayatbakhsh Abbasi
Pathology and stem cells Research Center, Kerman University of Medical Sciences, Kerman, Iran


| Elham Jafari
Professor of Internal Medicine Digestive Research Center, Kerman University of Medical Sciences,Kerman, Iran


| Mohammadjavad Zahedi
Professor of Internal Medicine Digestive Research Center, Kerman University of Medical Sciences,Kerman, Iran


| Sodaif Darvish Moghaddam
Pathology and Stem Cell Research Center,Kerman University of Medical Sciences, Kerman, Iran


| Aboozar Taghizadeh
Researcher, Kerman Digestive Research Center, Kerman University of Medical Sciences, Kerman,Iran


| Negin Kharazmi


نشانی اینترنتی http://mejdd.org/index.php/mejdd/article/view/2067
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi) 10.15171/middle east j di.v13i4.2067
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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