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Middle East Journal of Digestive Diseases، جلد ۱۳، شماره ۲، صفحات ۹۵-۱۰۲
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عنوان انگلیسی Prevalence of Hepatitis B and C Infections and Associated Risk Factors in Pars Cohort Study, Southern Iran
چکیده انگلیسی مقاله BACKGROUND: Hepatitis B and C virus (HBV and HCV) infections rank among the most frequent infectious diseases with a rising worldwide burden. However, their epidemiology and risk factors are understudied in many regions, including Iran. METHODS: This study was conducted as part of the Pars Cohort Study (PCS) in Valashahr district, Fars province (2012-2014). Participants received venipuncture for HBsAg and HCV antibody, followed by Polymerase Chain Reaction (PCR) testing. All infected people and their comparison groups completed a risk assessment questionnaire. RESULTS: Overall, 9,269 people participated in the study; the majority were women and of Fars ethnicity. Prevalence of HBsAg and HCV antibody was 2.3% (n=215) and 0.3% (n=26), from whom 23% (n=47) and 13% (n=3) had indications for treatment, respectively. During follow-up, among HBsAg-positive individuals who were not on treatment, 62% tested negative for HBsAg, and in 2% HBV DNA had risen to treatment levels. Risk factors for HBV infection were illiteracy [OR=3.43, 95% CI=1.1, 10.3], and Turk ethnicity compared to Fars [OR=1.58, 95% CI=1.1, 2.3]. History of blood transfusion [OR=2.00, 95% CI=1.1, 3.5] and history of drug use [OR=2.85, 95% CI=1.1, 7.4] were associated with HCV infection, after adjustment. CONCLUSIONS: Further epidemiological studies are needed to identify at-risk populations in different regions. Preventive interventions, including educational programs and transfusion safety strategies, are crucial for reducing the hepatitis burden.
کلیدواژه‌های انگلیسی مقاله Hepatitis B virus (HBV), Hepatitis C virus (HCV), Prevalence, Risk factors, Treatment, Iran
نویسندگان مقاله | Sanam Hariri
MPH Department, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.


| Sabereh Davari
Digestive Disease Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.


| Zeinab Malekzadeh
Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.


| Zahra Mohammadi
Digestive Oncology Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.


| Sahar Masoudi
Non-communicable Disease Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.


| Abdullah Gandomkar
Iran Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.


| Sedigheh Amini Kafiabad
Iran Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.


| Mahtab Maghsoudloo
Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.


| Shahin Merat
Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.


| Hossein Poustchi
Digestive Disease Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.


| Fatemeh Malekzadeh


نشانی اینترنتی http://mejdd.org/index.php/mejdd/article/view/2223
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