این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Middle East Journal of Digestive Diseases، جلد ۱۳، شماره ۲، صفحات ۱۱۵-۱۲۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Diagnostic Significance of Serum Fatty Acid Synthase in Patients with Pancreatic Cancer
چکیده انگلیسی مقاله BACKGROUND: Pancreatic cancer is considered as the most deadly tumor among gastrointestinal cancers because of its poor prognosis. The frequently deregulated pathway in the cancer cell is associated with an increased expression of various genes, including the synthesis of fatty acids. We aimed to evaluate the level of serum fatty acid synthase (FASN) as a diagnostic marker for early diagnosis of pancreatic cancer . METHODS: Serum FASN levels were measured by ELISA in 92 patients with pancreatic adenocarcinomas and in 92 healthy controls. Logistic regression analysis was used to identify independent predictors of certain diagnostic categories. RESULTS: Serum FASN levels were significantly higher in patients with pancreatic cancer than in healthy controls (1.35 [0.98-2.3] ng/mL vs 1.04 [0.19-1.34] ng/mL, p < 0.001) and in smokers compared to non-smokers (1.41 [0.79-2.52] ng/mL vs 1.07 [0.21-1.74] ng/mL, p < 0.001). FASN levels and smoking were associated with increased risk of PC (1.54 [1.1-2.14] ng/mL, p =0.011 and 5.69 [2.68-12.09] ng/mL, p < 0.001, respectively). CONCLUSIONS: Elevated serum FASN levels in patients with pancreatic cancer indicate the need for the production of large numbers of lipids for the survival and proliferation of human cancer cells and the diagnostic value of FASN as a new diagnostic biomarker.
کلیدواژه‌های انگلیسی مقاله Fatty acid synthase,Pancreatic cancer,Smoking, Biomarker
نویسندگان مقاله | Hamid Reza Fazli
Rheumatology Research Center, Golestan University of Medical Sciences, Gorgan, Iran


| Maliheh Moradzadeh
3Department of Biostaticstics, School of Health, Hamadan University of Medical sciences, Hamadan, Iran 4Department of Biostaticstics, School of Health, Golestan University of Medical sciences, Gorgan, Iran


| Zahra Mehrbakhsh
Liver and Pancreatobiliary Diseases Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran


| Maryam Sharafkhah
Liver and Pancreatobiliary Diseases Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran


| Sahar Masoudi
Liver and Pancreatobiliary Diseases Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran


| Akram Pourshams
Liver and Pancreatobiliary Diseases Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran


| Ashraf Mohamadkhani


نشانی اینترنتی http://mejdd.org/index.php/mejdd/article/view/2496
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات