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Middle East Journal of Digestive Diseases، جلد ۱۳، شماره ۱، صفحات ۵-۱۴
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عنوان انگلیسی An Overview of the Current Hepatitis B Treatment Strategies after Liver Transplantation
چکیده انگلیسی مقاله Currently, liver transplantation (LT) is considered as the only option for the treatment of patients with various causes of liver failure, including patients with chronic hepatitis B virus (HBV) infections. Overall, patients with HBV who undergo LT are at increased risk of hepatitis B infection recurrence. Although the current knowledge regarding the pathophysiology of this infection has been dramatically increased over the past few decades, it is still considered a complex disease process with varying degrees of clinical characteristics and changing patterns over time. There are various treatment strategies for preventing HBV recurrence in the LT setting. Generally, these regimens include oral nucleoside/nucleotide analogues (NAs), hepatitis B immune globulin (HBIG), and vaccines or the combination of these drugs. The treatment strategy of choice should be based on cost-effectiveness, along with other patients underlying conditions. In this case, studies indicate that potent NAs are more cost-effective than HBIG in most case scenarios. In this article, we aimed to review the general medications used in the prophylaxis of the recurrence of HBV infection after LT.
کلیدواژه‌های انگلیسی مقاله Liver transplantation,Hepatitis B,Treatment
نویسندگان مقاله | Arash Dooghaie Moghadam
Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Pegah Eslami
Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Amirreza Dowlati Beirami
Research Center for Cancer Screening and Epidemiology, AJA University of Medical Sciences, Tehran, Iran


| Shahrokh Iravani
Liver Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran


| Ermia Farokhi
Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences, Guilan, Iran


| Alireza Mansour-Ghanaei
Gastroenterology and Hepatobiliary Research Center, AJA University of Medical Sciences, Tehran


| Mahmood Reza Hashemi
Gastroenterology and Hepatobiliary Research Center, AJA University of Medical Sciences, Tehran


| Morteza Aghajanpoor Pasha
Research Center for Cancer Screening and Epidemiology, AJA University of Medical Sciences, Tehran, Iran


| Azim Mehrvar
Liver Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran


| Mohssen Nassiri-Toosi


نشانی اینترنتی http://mejdd.org/index.php/mejdd/article/view/2231
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Review Article
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