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Middle East Journal of Digestive Diseases، جلد ۱۲، شماره ۴، صفحات ۲۲۹-۲۳۷
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چکیده فارسی مقاله
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عنوان انگلیسی Novel Therapeutic Strategies for Celiac Disease
چکیده انگلیسی مقاله Celiac disease (CeD) is a widespread autoimmune enteropathy caused by dietary gluten peptides in genetically susceptible individuals, which includes a range of intestinal and extraintestinal manifestations. Currently, there is no effective treatment for CeD other than strict adherence to a gluten-free diet (GFD). However, persistent or frequent symptoms and also partial villus atrophy were observed in some patients with CeD due to intentional or inadvertent gluten exposure during the use of GFD. It means that GFD alone is not enough to control CeD symptoms and long-term complications. Accordingly, new therapeutic approaches for CeD treatment such as gluten proteolysis, removing gluten from the digestive tract, promoting tight junction assembly, inhibiting intestinal tissue transglutaminase 2, using probiotics, and developing immunotherapeutic methods have been proposed through different strategies. This review focused on discussing the novel therapeutic strategies for CeD management.
کلیدواژه‌های انگلیسی مقاله Celiac disease,Gluten,Auto-immune,Villous atrophy,Diet, Gluten-free,Therapy
نویسندگان مقاله | Nastaran Asri
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Mohammad Rostami-Nejad
Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Mostafa Rezaei-Tavirani
Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Mohammadreza Razzaghi
Gastroenterologist, Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Hamid Asadzadeh-Aghdaei
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Mohammad Reza Zali


نشانی اینترنتی http://mejdd.org/index.php/mejdd/article/view/2325
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Review Article
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