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Journal of Midwifery and Reproductive Health، جلد ۹، شماره ۳، صفحات ۲۸۸۳-۲۸۸۸
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عنوان انگلیسی The Prevalence of High-risk Human Papillomavirus Type 16 and 18 in Women in Rasht-Iran
چکیده انگلیسی مقاله Background & aim: Cervical cancer is one of the leading causes of cancer death among females. Human papillomavirus (HPV) is the most important risk factor for cervical cancer. The aim of the present study was to explore the prevalence of high-risk human papillomavirus types 16 and 18 in women who undergo HPV test.Methods: In this descriptive epidemiological study, which was conducted in Mehr Medical Institute, Rasht, Iran from 2019 to 2020, two cervical samples were obtained from each of 301 patients for cytological and real-time PCR evaluation. Genotyping the samples was carried out using the Real-Time PCR technique. Different genotypes were divided into the following groups: 16 and 18 genotypes, other high risk genotypes, possibly low risk and high risk genotypes.Results: The prevalence of HPV types in the study participants with a mean age of 33.4± 6.5 (18-61) years were 36.5% (n=110). HPV16 and 18 were detected in 28 (25.7%) and 7 patients (6.4%), respectively. Histopathological findings among HPV positive and negative participants were similar. HPV distribution according to women´s age was: group 1 (20-24.9 years, 47%), group 2 (25-29.9 years, 42.6%), group 3 (30-34.9 years, 40.4%), group 4 (35-39.9 years, 27.6%) and group 5 (40≤ years, 28.3%).Conclusion: The general percentage of HPV positive patients in the local area can be compared to the previous literature. The study includes updates on the prevalence and type of HPV distribution between women of Guilan province in Iran. 
کلیدواژه‌های انگلیسی مقاله Human papillomavirus 16, Human Papillomavirus 18, Uterine Cervical Neoplasms, Papanicolaou Test, Real-time polymerase chain reaction
نویسندگان مقاله | Gholam Reza Pourseify
PhD Student of Genetic, Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran


| Marzieh Mehrafza
Fellowship of Infertility and IVF, Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran


| Azadeh Raoufi
Graduated, Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran


| Zahra Nikpouri
Medical Doctor, Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran


| Marjan Askari
Assistant Professor, Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran


| Elmira Hosseinzadeh
Graduated, Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran


| Pegah Rafia
Graduated, Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran


| Kimiya Razeghian
General Practitioner, Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran


| Ahmad Hosseini
Professor, Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran
نشانی اینترنتی https://jmrh.mums.ac.ir/article_18376.html
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نوع مقاله منتشر شده Original Research Article
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