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Journal of Food Quality and Hazards Control، جلد ۸، شماره ۱، صفحات ۴۵-۴۹
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Using Comet Assay for Genotoxic Evaluation of Zataria multiflora Boiss., An Iranian Endemic Plant
چکیده انگلیسی مقاله Background: Zataria multiflora Boiss. (Avishan-e Shirazi), as an Iranian endemic plant, belongs to the Lamiaceae family and may be used as a food preservative. This study aimed to detect potential genotoxic effects of Z. multiflora extract.  Methods: Hydro-alcoholic extract of Z. multiflora was prepared. Human B lymphocytes were treated with 1% extract within 3 and 24 h. Sterile Phosphate Buffered Saline (PBS) and cisplatin were used as negative and positive controls, respectively. DNA damage profiles were examined using comet assay (Single Cell Gel Electrophoresis). Data were statistically analyzed by SPSS software v. 21. Results: No statistically significant (p=0.071) DNA damage was observed in B lymphocytes treated with either Z. multiflora extract or PBS after 3 and 24 h. However, there was a statistically significant difference (p=0.0001) between DNA damage in B lymphocytes that treated with cisplatin and Z. multiflora after 3 and 24 h. Conclusion: The comet assay used in the current study showed that Z. multiflora had no genotoxic effect. DOI: 10.18502/jfqhc.8.1.5463
کلیدواژه‌های انگلیسی مقاله Thymus Plant, Comet Assay, Mutagenicity Tests, DNA Damage, Food Safety
نویسندگان مقاله | Z. Ayubi
Department of Medical Parasitology and Mycology, Afzalipoor Medical School, Kerman Medical University, Kerman, Iran


| A.A. Jafari
Department of Medical Parasitology and Mycology, Medical School, Shahid Sadougi University of Medical Sciences, Yazd, Iran


| S.A. Ayatollahi-Mousavi
Department of Medical Parasitology and Mycology, Afzalipoor Medical School, Kerman Medical University, Kerman, Iran


| H. Jafari
Department of Food and Drug Control, School of Pharmacy, Tehran University of Medical Sciences, Tehran Iran


| M. Panddeh
Department of Biochemistry, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
نشانی اینترنتی http://jfqhc.ssu.ac.ir/browse.php?a_code=A-10-234-1&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Short communication
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