این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Journal of Livestock Science and Technology، جلد ۸، شماره ۲، صفحات ۴۵-۵۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Genome-wide association study and gene ontology for growth and wool characteristics in Zandi sheep
چکیده انگلیسی مقاله Genome-wide association studies (GWAS) is a major procedure for studying the genetics of complex economically important traits in sheep. The objective of this study was to determine the genomic regions affecting some growth traits and wool characteristics in Zandi sheep. This study is GWAS implementing a medium-density single nucleotide polymorphism (SNP) panel to determine the putative chromosome area affecting some growth and wool traits in a fat-tailed sheep breed, simultaneously. We used a selective genomic approach sampling DNA from animals at the extreme ends using the estimated breeding values derived from a total population size of over 5,000 animals. The examined phenotypic data included the birth weight, weaning weight, 6, 9, and 12-months after birth weight, pre- and post-weaning average daily gain, fiber diameter (micron), prickle factor (%), staple length (mm), kemp (%) and medullated fiber. Genome-wide association analyses were performed based on the mixed linear model. Twenty-three regions, in which four were associated with more than one trait, located on 12 chromosomeswere associated with the studied growth and wool traits (p <­5×10−6). These genomic regions overlapping with KCNIP4, PPARGC1A, ASAP1, ANK2, WWOX, SYNE1, FBXO5, AKAP6, FABP3, ANGPTL4, ATP6V1B2, PARK2, and KRTAP11-1 genes, were associated with postnatal growth, regulation of metabolic pathways, skeletal muscle differentiation, and bone growth. Gene ontology term enrichment analysis revealed that genes involved in positive regulation of muscle structure, and muscle tissue development were over-represented in the identified candidate genes.
کلیدواژه‌های انگلیسی مقاله Candidate Gene, genome-wide association, Growth, sheep, wool
نویسندگان مقاله Hossein Mohammadi |
Department of Animal Science, Faculty of Agricultural Sciences, University of Tabriz, Tabriz, East Azerbaijan, Iran.

Seyed Abbas Rafat |
Department of Animal Science, Faculty of Agricultural Sciences, University of Tabriz, Tabriz, East Azerbaijan, Iran.

Hossein Moradi Shahrbabak |
Department of Animal Sciences, University College of Agriculture and Natural Resources, University of Tehran, Karaj, Alborz, Iran.

Jalil Shodja |
Department of Animal Science, Faculty of Agricultural Sciences, University of Tabriz, Tabriz, East Azerbaijan, Iran.

Mohammad Hossein Moradi |
Department of Animal Sciences, Faculty of Agriculture and Natural Resources, Arak University, Arak, Markazi, Iran.

نشانی اینترنتی https://lst.uk.ac.ir/article_2752_63ae66ffa925cee9cf172f9b32a28d86.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات