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Molecular Biology Research Communications، جلد ۱۰، شماره ۴، صفحات ۱۶۵-۱۷۰
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عنوان انگلیسی Investigation of p16 protein expression and its association with histopathologic parameters in breast cancer
چکیده انگلیسی مقاله We investigated the association between p16 expression and histopathologic parameters including size, neural and vascular invasion, and lymph node involvement in breast cancer. 58 specimens from patients with different grades of breast cancer were included. Hematoxylin and eosin and immunohistochemistry staining for p16 was performed. 5 patients (8.6%) had grade I, 23 (39.7%) had grade II, and 30 (51.7%) had grade III breast cancer. Assessment of the tumor size showed that 5 (8.6%) tumors had a size of ≤2cm, 29 (50%) were between 2-5 cm and 24 (41.4%) had a size of ≥5cm. Moreover, 45 (77.6%) of the included patients had axillary lymph node involvement. Investigation of association between p16 positivity with pathological parameters in three groups with positivity to p16 (1-25%, 26-75%, >75%) showed that there was no association between p16 positivity and other parameters including histologic score (p=0.44), tumor size (p=0.77), neural invasion (p=0.79), perivascular invasion (p=0.98) and the number of involved LNs (p=0.49). From the group including eight patients with >75% p16 positivity, seven (87.5%) were found with neural invasion and two (25%) with perivascular invasion. P16 positivity was not associated with size, neural and vascular invasion, and LN involvement in breast cancer.
کلیدواژه‌های انگلیسی مقاله Breast cancer, p16, Neural invasion, Vascular invasion, Nodal involvement
نویسندگان مقاله Siamak Naji-Haddadi |
Mahzad Women’s Hospital Urmia Medical Sciences University (UMSU), Urmia, Iran

Daniel Elieh-Ali-Komi |
Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran

Saeid Aghayan |
Department of Pathology, Urmia University of Medical Sciences, Urmia, Iran

Rahim Asghari |
Immune Cell Therapy, Stem Cell Transplantation Research Center (HİSRC), Urmia Medical University (UMSU), Urmia, Iran

Javad Rasouli |
Department of Biostatistics and Epidemiology, School of Medicine Urmia University of Medical Sciences, Urmia, Iran

نشانی اینترنتی https://mbrc.shirazu.ac.ir/article_6444_fe3d6ad6fe373ff384ed863fb8156b9c.pdf
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