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Molecular Biology Research Communications، جلد ۹، شماره ۴، صفحات ۱۶۹-۱۷۲
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عنوان انگلیسی Differential expression of inflammatory responsive genes between chronic periodontitis and periodontally affected bronchiectasis patients
چکیده انگلیسی مقاله The study aimed to investigate differential expression of targeted inflammatory-immune responsive genes [LTA, LTB, TNFSF4, TNFSF11/RANKL, TNFSF13, TNFSF13B, TNFRSF11B/ Osteoprotegerin; OPG and GFPT1/GFA ] in gingival tissues of bronchiectasis patients having chronic periodontitis in North central Indian population. Gingival tissues were collected from 30 systemically healthy chronic periodontitis patients (CP), 30 bronchiectasis patients with chronic periodontitis (B+CP), 3 systemically healthy with healthy gingiva (healthy control; HC) and 3 bronchiectasis with healthy gingiva (bronchiectasis control; BC). Statistical analysis revealed 7 genes to be significantly upregulated on comparing CP with B+CP i.e LTA (p < 0.0001) in B+CP while LTB (p < 0.0001), TNFSF4 (P=0.0003), TNFSF11 (p < 0.0001), TNFSF13 (P=0.0003), TNFSF13B (p < 0.0001) and TNFRSF11B (P=0.0004) in CP group. LTA (Lymphotoxin A) gene could be a potential genetic marker in bronchiectasis patients with chronic periodontitis.
کلیدواژه‌های انگلیسی مقاله Tumor necrosis factor superfamily, Lymphotoxin A gene, Bronchiectasis, Chronic periodontitis, Expression
نویسندگان مقاله Abhaya Gupta |
Department of Periodontology, Faculty of Dental Sciences, King George’s Medical University, Uttar Pradesh, Lucknow, India

Neetu Singh |
Department of Molecular Biology, Center for Advanced Research, King George’s Medical University, Uttar Pradesh, Lucknow, India

Anil Kumar |
Department of Molecular Biology, Center for Advanced Research, King George’s Medical University, Uttar Pradesh, Lucknow, India

Umesh Pratap Verma |
Department of Periodontology, Faculty of Dental Sciences, King George’s Medical University, Uttar Pradesh, Lucknow, India

Ajay Kumar Verma |
Department of Respiratory Medicine, King George’s Medical University, Uttar Pradesh, Lucknow, India

Hari Shyam |
Department of Molecular Biology, Center for Advanced Research, King George’s Medical University, Uttar Pradesh, Lucknow, India

Nand Lal |
Department of Periodontology, Faculty of Dental Sciences, King George’s Medical University, Uttar Pradesh, Lucknow, India

Surya Kant |
Department of Respiratory Medicine, King George’s Medical University, Uttar Pradesh, Lucknow, India

Ankur Kumari |
Department of Periodontology, Faculty of Dental Sciences, King George’s Medical University, Uttar Pradesh, Lucknow, India

نشانی اینترنتی https://mbrc.shirazu.ac.ir/article_5800_48d915ce3f3d4b87f5082e5f803c39b4.pdf
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