این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Addiction and Health، جلد ۱۳، شماره ۴، صفحات ۲۴۲-۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Do Opioid Addicts Require Higher Doses of Heparin During Percutaneous Coronary Intervention?
چکیده انگلیسی مقاله Background: Patients who undergo percutaneous coronary intervention (PCI) receive anticoagulants, most commonly heparin to prevent thrombotic events during the procedure. Opioid addicts may require higher doses of heparin for PCI. We aimed to compare the effect of heparin on activated clotting time (ACT) between opioid addicts and non-addicts prior to and during PCI.Methods: This comparative study included 107 patients scheduled for elective PCI, of whom 50 were opioid addicts and 57 non-addicts. Patients’ baseline characteristics including age, gender, weight, comorbidities, drug history, and smoking were recorded. Prothrombin time (PT), partial thromboplastin time (PTT), international normalized ratio (INR), and platelet count were measured in venous blood samples collected from all participants. All patients underwent PCI through femoral access. They received 100 IU/kg heparin right at the beginning of the procedure. ACT was measured at 2 and 30 minutes.Findings: Age, gender, weight, and the amount of heparin used were comparable between groups. As for general characteristics, the number of patients with hyperlipidemia was significantly higher in non-addicts (P = 0.031), and cigarette smoking was higher in opioid addicts (P < 0.001). No significant difference was found between the groups regarding PT, PTT, INR, and platelet count (P > 0.050). ACT at 2 and 30 min were significantly lower in opioid addicts (P < 0.001). Taking other variables into account, ACT at 2 min was directly correlated with drug history of aspirin in opioid addicts (P = 0.031) and inversely correlated with cigarette smoking in non-addicts (P = 0.023).Conclusion: Opioid addicts may require higher doses of heparin in PCI for the prevention of thrombotic complications compared to non-addicts.
کلیدواژه‌های انگلیسی مقاله Opioids, Percutaneous Coronary Intervention, Heparin, Activated Clotting Time
نویسندگان مقاله Tahereh Afaghnia |
Student Research Committee, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

Mohammad Nasim-Tajik |
Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

Elham Boushehri |
Department of Medical Education, School of Health, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

Marzieh Nikparvar |
Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

Abdollah Gharibzade |
Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

Hossein Farshidi |
Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

نشانی اینترنتی http://ahj.kmu.ac.ir/article_91823_7bb21a9ade55acbd7027fcce0000a647.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات