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Journal of Reproduction and Infertility، جلد ۲۲، شماره ۱، صفحات ۷۰-۷۳
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عنوان انگلیسی The First Livebirth Using Warmed Oocytes by a Semi-Automated Vitrification Procedure
چکیده انگلیسی مقاله Background: The first successful livebirth using warmed oocytes (vitrified by the GAVITM system) is reported in this paper. Embryologists throughout the world have vitrified oocytes using a manual technique which is susceptible to error and variation. In this era of automated laboratory procedures, vitrification was made semi-automatic by using the GAVITM system. Case presentation: Donor oocytes were initially vitrified using the GAVITM system. They remained in the clinic's oocyte bank until they were allocated to the patient. Donor oocytes were warmed as per Genea BIOMEDX protocol and inseminated to create embryos. Resulting embryos for the 42-year-old patient were cultured to the blastocyst stage, biopsied to perform PGT-A, using next generation sequencing and subsequently vitrified. The patient underwent a single euploid transfer in a frozen embryo transfer cycle which resulted in a healthy livebirth. Conclusion: The introduction of a semi-automated system should minimize the risk to the oocytes, standardize the procedure worldwide and potentially reduce the laboratory time taken by the embryologists. This case report demonstrates the safety of the technology used for vitrification, but larger randomized studies need to be performed to demonstrate the safety and efficacy of newer technologies like the GAVITM system before adopting it as a standard laboratory procedure.
کلیدواژه‌های انگلیسی مقاله Cryopreservation, GAVITM, Oocytes, PGT-A, Semi-automated vitrification system, Vitrification
نویسندگان مقاله | Xavier Brunetti
The Centre for Reproductive and Genetic Health, London, United Kingdom


| Suzanne Cawood
The Centre for Reproductive and Genetic Health, London, United Kingdom


| Matthew Gaunt
The Centre for Reproductive and Genetic Health, London, United Kingdom


| Wael Saab
The Centre for Reproductive and Genetic Health, London, United Kingdom


| Paul Serhal
The Centre for Reproductive and Genetic Health, London, United Kingdom


| Srividya Seshadri
The Centre for Reproductive and Genetic Health, London, United Kingdom
نشانی اینترنتی https://www.jri.ir/article/120092
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