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Journal of Sciences Islamic Republic of Iran، جلد ۳۱، شماره ۴، صفحات ۳۵۷-۳۶۸
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عنوان انگلیسی In vivo and In vitro Biocompatibility Study of Fe3O4@ZnO and Fe3O4@SiO2 as Photosensitizer for Targeted Breast Cancer Drug Delivery
چکیده انگلیسی مقاله The present study aimed to prepare Fe3O4 nanocarriers (NCs) by a thermal treatment method. After the Fe3O4 (Fe) NCs was prepared, zinc oxide and silica nanoparticles were added to it as Photosensitizer. The structure, morphology, and magnetic properties of Fe3O4@ZnO (Fe@Zn) and Fe3O4@SiO2 (Fe@Si) NCs were determined by XRD, FT-IR, FESEM, and VSM. Then, the loading and drug release of Fe, Fe@Zn, and Fe@Si NCs were investigated. The curcumin (CUR) release of Fe@Zn+CUR and Fe@Si+CUR increased from 30% and 26% at pH 7.4 to 53% and 57% at pH 5.5, respectively. The cytotoxicity of Fe@Zn and Fe@Si NCs were determined by MTT assay, hemolysis test, acute toxicity, and lethal dose test. The results showed that Fe@Zn and Fe@Si were appropriate for Photodynamic Therapy (PDT) and in the next step, the effect of Fe@Zn, Fe@Si, Fe@Zn+CUR, and Fe@Si+CUR NCs on MCF-7 cells under visible light were studied. Finally, the ranking of the destruction of cancerous cells of MCF-7 using NCs under visible light was: Fe@Zn+CUR>Fe@Zn>Fe@Si+CUR>Fe@Si.
کلیدواژه‌های انگلیسی مقاله Photosensitizer, drug delivery, Curcumin, Cytotoxicity, Magnetic properties
نویسندگان مقاله Ehsan Naderi |
Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Islamic Republic of Iran

Mahmoud Naseri |
Department of Physics, Malayer University, Malayer, Iran.

Heidar Taimouri Rad |
Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Islamic Republic of Iran

Reza Zolfaghari Emameh |
Department of Energy and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), 14965/161, Tehran, Islamic Republic of Iran

Gholamreza Farnoosh |
Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Islamic Republic of Iran

Ramezan Ali Taheri |
Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Islamic Republic of Iran

نشانی اینترنتی https://jsciences.ut.ac.ir/article_78695_1e7832e2d656ca2077b1c8b2c6a5ae22.pdf
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