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Physiology and Pharmacology، جلد ۲۶، شماره ۱، صفحات ۲۰-۲۹
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عنوان انگلیسی Naringin ameliorates cognitive impairment in streptozotocin/nicotinamide induced type 2 diabetes in Wistar rats
چکیده انگلیسی مقاله Introduction: Psychomotor slowing and reduced mental flexibility are symptoms of cognitive decline that can occur in type 2 diabetes disease (TD2). Strategies that combine the control of hyperglycaemia with prevention of cognitive decline are desirable. Thus, this study reports the effect of naringin on cognitive deficit in diabetic rats. Methods: TD2 in Wistar rats was induced with nicotinamide/streptozotocin (NA/STZ). Naringin (50 and 100 mg/kg) or glibenclamide (5mg/kg) was administered for 30 days to diabetic rats. Cognitive performance was investigated using the Morris water maze. Serum glucose, lipid profiles, brain tumour necrosis factor alpha (TNF-α) and acetylcholinesterase (AChE) activity were determined. Results: Naringin and glibenclamide significantly reduced the escape latency, increased the time spent in the correct quadrant and number of entries in diabetic rats. Also, naringin reduced blood glucose, serum cholesterol, low-density lipoprotein cholesterol levels, triglycerides and prevented a decrease in the level of high-density lipoprotein cholesterol, in diabetic rats. Naringin and glibenclamide treated diabetic rats showed a significant low levels of AChE activity and TNF-α. Conclusion: Naringin ameliorates diabetes induced cognitive deficit via reduction of inflammation, hyperglycemia, hyperlipidaemia and AChE activity
کلیدواژه‌های انگلیسی مقاله Naringin, Diabetes, Cognitive decline, Inflammation, Acetylcholinesterase.
نویسندگان مقاله | Abiodun Oyindamola O
Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria


| Bakre Adewale G
Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria


| Adekoya Christiana T
Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria


| Kazeem Adebola I
Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria


| Oke Tolulope A
Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria


| Ujomu Tejumade S
Department of Anatomy, Physiology and Pharmacology, Lead City University, Ibadan, Nigeria
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-10-1374-2&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pharmacokinetics/Dynamics
نوع مقاله منتشر شده Experimental research article
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