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The Archives of Bone and Joint Surgery، جلد ۱۰، شماره ۴، صفحات ۳۲۰-۳۲۷
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عنوان انگلیسی The Use of Calcium Sulphate Beads in the Management of Osteomyelitis of Femur and Tibia: A Systematic Review
چکیده انگلیسی مقاله Background: Calcium sulphate is a recent alternative for delayed antibiotic elution in infected bones and joints. The purpose of this study is to evaluate the use of antibiotic impregnated calcium sulphate (AICS) beads in the management of infected tibia and femur, with regards to patient outcomes and complication rates (including reinfection rate, remission rate and :union: rate).Methods: Searches of AMED, CINAHL, EMBASE, EMCARE, Medline, PubMed and Google Scholar were conducted in June 2020, with the mesh terms: “Calcium sulphate beads” or “Calcium sulfate beads” or “antibiotic beads” or “Stimulan” AND “Bone infection” or “Osteomyelitis” or “Debridement” AND “Tibia” or “Femur”. Risk of bias was assessed using the Risk of Bias in Non-randomised Studies of interventions (ROBINS-i) tool, and quality assessed via the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) criteria.Results: Out of 104 relevant papers, 10 met the inclusion criteria for data extraction. Total infection remission was 6.8%, which was greater than that of polymethylmethacrylate (PMMA, 21.2%). Complication rates varied. The main issue regarding AICS use was wound drainage, which was considerably higher in studies involving treatment of tibia alone. Studies using PMMA did not experience this issue, but there were a few incidences of superficial pin tract infection following surgery.Conclusion: Where AICS was used, it was consistently effective at infection eradication, despite variation in causative organism and location of bead placement. Wound drainage varied and was higher in papers regarding tibial cases alone.Level of evidence: III
کلیدواژه‌های انگلیسی مقاله antibiotic beads, bone infection, calcium sulphate beads, long-bone osteomyelitis, Stimulan
نویسندگان مقاله | Azeem Thahir
ja Krkovic PhD FRCS1 1 Department of Trauma and Orthopaedics, Addenbrookes Major Trauma Unit, Cambridge University Hospitals, Hills Road, Cambridge, United Kingdom


| Jiang An Lim
School of Clinical Medicine, University of Cambridge, Hills Road, Cambridge, United Kingdom


| Cavan West
School of Clinical Medicine, University of Cambridge, Hills Road, Cambridge, United Kingdom


| Matija Krkovic
Department of Trauma and Orthopaedics, Addenbrookes Major Trauma Unit, Cambridge University Hospitals, Hills Road, Cambridge, United Kingdom
نشانی اینترنتی https://abjs.mums.ac.ir/article_18655.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده SYSTEMATIC REVIEW
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