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Research in Pharmaceutical Sciences، جلد ۱۷، شماره ۳، صفحات ۳۲۴-۳۳۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Beneficial effects of kebar grass (Biophytum petersianum klotzsch) ethanol extract to increase motor reflex and spatial memory in mice offspring (Mus musculus) from lactating mothers exposed to carbofuran
چکیده انگلیسی مقاله Background and purpose : This study aimed to determine the potency of kebar grass ethanol extract to overcome an increase in cerebellar neuronal cell necrosis, which has an impact on decreasing motor reflex function and spatial memory of mice from lactating mothers exposed to carbofuran. Experimental approach : Forty lactating mice were divided into four groups, 10 each; including control, T1 (carbofuran 0.0125 mg/day), T2 (vitamin C 5 mg + carbofuran 0.0125 mg/day), T3 (kebar grass extract 3.375 mg + carbofuran 0.0125 mg/day). The mice were orally administered with carbofuran, vitamin C, and kebar grass extract on days 0 to 14 postnatal. On the 15 th day, brains of the mice were necropsied to measure the levels of malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione (GSH), H&E staining; motor reflex tests were performed on 10-day-old mice, and the mice aged 30 days were tested on their swimming and spatial memory. Findings / Results : Carbofuran caused an increase in MDA, GSH, neuronal cell necrosis, surface righting reflex, a decrease in SOD, swimming ability, and spatial memory. Kebar grass extract and vitamin C administration decreased MDA, GSH, neuron necrosis, surface righting reflex, and increased SOD, swimming ability, and spatial memory. Conclusion and implications : Exposing to carbofuran in lactating mice caused brain oxidative stress, impaired motor reflexes, and spatial memory in mice offspring. Kebar grass extract and vitamin C administration prevented brain oxidative stress and inhibited disorders in motor reflexes, and spatial memory in mice offspring. Kebar grass extract administration was more effective than vitamin C.
کلیدواژه‌های انگلیسی مقاله Carbofuran,Cerebellum,Kebar grass,Lactation,Pesticide stress,Vitamin C.
نویسندگان مقاله | Epy Muhammad Luqman
1Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia.


| Eka Pramyrtha Hestianah
1Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia.


| Widjiati Widjiati
1Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia.


| Suryo Kuncorojakti Kuncorojakti
2Department of Reproduction, Faculty of Veterinary Medicine, Universitas Brawijaya, Malang, Indonesia.


| Viski Fitri Hendrawan


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/2130
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