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Iranian Journal of Medical Sciences، جلد ۴۷، شماره ۳، صفحات ۲۲۷-۲۳۵
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عنوان انگلیسی Quality of Life and Its Determinants in Liver Transplantation Candidates: A Missed Link in Liver Care Program during the Waiting Time for Liver Transplantation
چکیده انگلیسی مقاله Background: The health-related quality of life (HRQOL) in the before liver transplantation (LT) stage has not been studied as much as that after the LT stage. We aimed to assess HRQOL and its determinants before the LT stage. Methods: As a cross-sectional study, HRQOL of all adult patients (n=632) referred to the LT center of Shiraz, Iran in 2018-2019 were assessed. Demographic, socioeconomic, medical, and paraclinical data were requested. Physical (PCS) and mental (MCS) aspects of HRQOL were assessed using the SF36 questionnaire. Univariable, multivariable (linear regression), and confirmatory factor analysis were performed utilizing SPSS 20 and Mplus 6.1 software. P< 0.05 was considered to be significant.Results: The mean age of the patients was 47.6±12.3 years, while 414 (65.6%) were men, and the mean, score of the model for end-stage liver disease (MELD) was 18.36±5.58. The mean score of QOL, PCS, and MCS was 50.01±21.73, 46.23±23.23, and 53.78±23.91 (out of 100), respectively. Vitality had the most association with HRQOL, while role limitations had the lowest. The multivariable analysis revealed that unemployment (P< 0.001), anemia (P=0.005), weight loss (P=0.005), diabetes mellitus (DM) (P=0.009), low MELD score (P=0.027), and drug use (P=0.03) were the significant determinants of HRQOL, respectively.Conclusion: The present study showed that HRQOL in the LT candidates was at the intermediate level, while their PCS and MCS are at the low and moderate levels, respectively. Furthermore, physical performance, job status, anemia, weight loss, MELD score, DM, and drug use should be considered as the significant determinants of HRQOL in the LT candidates.
کلیدواژه‌های انگلیسی مقاله Quality of life, Liver, Transplantation, Waiting list
نویسندگان مقاله Kamran Bagheri Lankarani |
Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran

Behnam Honarvar |
Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran

Mahsa Akbari |
Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran

Naghmeh Bozorgnia |
Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran

Maryam Rabiey Faradonbeh |
Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran

Morteza Bagherpour |
Department of Industrial Engineering, Iran University of Science and Technology, Tehran, Iran

Saman Nikeghbalian |
Shiraz Organ Transplant Center, Shiraz University of Medical Sciences, Shiraz, Iran

Alireza Shamsaeefar |
Shiraz Organ Transplant Center, Shiraz University of Medical Sciences, Shiraz, Iran

Seyed Ali Malekhosseini |
Shiraz Organ Transplant Center, Shiraz University of Medical Sciences, Shiraz, Iran

نشانی اینترنتی https://ijms.sums.ac.ir/article_47919_575f43810b04f541a15991040ede9636.pdf
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