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Basic and Clinical Neuroscience، جلد ۱۳، شماره ۲، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Short communication: The effect of different concentrations of methylprednisolone on survival, proliferation and migration of neural stem/progenitor cells
چکیده انگلیسی مقاله Introduction: To address the question whether combination of methylprednisolone (MP) as an anti-inflammatory drug used in neurodegenerative diseases and neural stem/progenitor cells (NS/PCs) is safe, the present study was designed. Methods: Embryonic rat NS/PCs were exposed to different concentrations of MP and survival by MTT assay, proliferation by analyzing the number and diameter of neurospheres and the migration of the cells by neurosphere assay were evaluated. Results: The viability of NS/PCs reduced following exposure to 10, 15 and 20 µg/ml of MP. In addition, although the number of neurospheres didn't change, exposure to different concentrations of MP resulted in formation of smaller neurospheres. Despite these undesirable effects, the highest concentration of MP (20 μg/ml) increased the migration capacity of the NS/PCs. Conclusion: The combination of MP and NS/PCs is not recommended due to the adverse effects of MP on survival and proliferation of NS/PCs.
کلیدواژه‌های انگلیسی مقاله Methylprednisolone, Neural stem cells, proliferation, survival, migration
نویسندگان مقاله | Zohreh Bagheri
Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran


| Fatemeh Shamsi
Department of Neuroscience, School of advanced medical sciences and technologies, Shiraz University of Medical Sciences, Shiraz, Iran


| Zahra Zeraatpisheh
Department of Neuroscience, School of advanced medical sciences and technologies, Shiraz University of Medical Sciences, Shiraz, Iran


| Mahin Salman Nejad
Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.


| Ahmad Soltani
Department of Neurosurgery, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.


| Hadi Aligholi
Department of Neuroscience, School of advanced medical sciences and technologies, Shiraz University of Medical Sciences, Shiraz, Iran
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-35-4&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Cellular and molecular Neuroscience
نوع مقاله منتشر شده Original
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