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Basic and Clinical Neuroscience، جلد ۱۳، شماره ۲، صفحات ۰-۰
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عنوان انگلیسی Cardiovascular effect of dorsal periaqueductal gray during LPS- induced hypotension
چکیده انگلیسی مقاله Introduction: The central mechanism related to the cardiovascular response to lipopolysaccharide (LPS) - induced hypotension is not completely determined and it is suggested numerous brain areas such as dorsal periaqueductal gray (dPAG) are involved. In the current work the cardiovascular effect of the dPAG during LPS-induced hypotension was investigated. Methods: Animals divided into four groups including 1) Control (Saline microinjected into dPAG), 2) Lidocaine 2%, 3) LPS (intravenously injected), and 4) Lidocaine + LPS were used. Catheterization of the femoral artery and vein was performed for the recording of blood pressure and LPS injection, respectively. Saline and lidocaine were microinjected into the dPAG nucleus then, LPS injection was performed. The changes (∆) of systolic blood pressure (SBP), mean arterial pressure (MAP) and heart rate (HR) were calculated over time and was compared with those control and LPS groups. Results: LPS significantly declined ∆MAP and ∆SBP (P< 0.05) and did not change the ∆HR than the control. Lidocaine did not significantly affect basic ∆SBP, ∆MAP and ∆HR compared to the control. Injection of lidocaine before LPS significantly attenuated reduction of ∆SBP and ∆MAP evoked by LPS (P< 0.05). Conclusion: Our data showed that blockade of the dPAG by lidocaine significantly ameliorates the hypotension induced by LPS. It confirms involvement of the dPAG in cardiovascular regulation during LPS-induced hypotension.
کلیدواژه‌های انگلیسی مقاله Dorsal periaqueductal gray, Lidocaine, Lipopolysaccharide, Blood Pressure
نویسندگان مقاله | Iraj Mirzaii-Dizgah
Department of Physiology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran


| Mohammad Naser Shafei
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Reza Mohebbati
Department of Physiology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.


| Vajiheh Alikhani
Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-2830-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Behavioral Neuroscience
نوع مقاله منتشر شده Original
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