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Basic and Clinical Neuroscience، جلد ۱۳، شماره ۲، صفحات ۰-۰
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چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Role of amygdala-infralimbic cortex circuitry in glucocorticoid-induced facilitation of auditory fear memory extinction
چکیده انگلیسی مقاله Purpose: The basolateral amygdala (BLA) and infralimbic area (IL) of medial prefrontal cortex (mPFC) are two inter-connected brain structures that mediate both fear memory expression and extinction. Besides the well-known role of the BLA in the acquisition and expression of fear memory, projections from IL to BLA inhibit fear expression and have a critical role in fear extinction. However, the details of IL-BLA interaction remain unclear. Here, we aimed to investigate the role of functional reciprocal interactions between BLA and IL in mediating fear memory extinction. Methods:  Using lidocaine (LID), male rats underwent unilateral or bilateral inactivation of the BLA and then unilateral intra-IL infusion of CORT, prior to extinction training of auditory fear conditioning paradigm. Freezing behavior was reported as an index for the measurement of  conditioned fear. Infusions were performed before the extinction training, allowing to examine the effects on fear expression and also further extinction memory. Experiments 1-3 investigated the effects of left or right infusion of CORT into IL, and LID unilaterally into BLA on fear memory extinction. Results: Results showed that intra-IL infusion of CORT in the right hemisphere reduced freezing behavior when administrated before the extinction training. Auditory fear memory extinction was impaired by asymmetric inactivation of BLA and CORT infusion in the right IL; however, the same effect was not observed with symmetric inactivation of BLA. Conclusion: It is concluded that that the IL-BLA neural circuit may provide additional evidence to contribution of this circuit in auditory fear extinction. This study demonstrate dissociable roles for right or left BLA in subserving the auditory fear extinction. Our finding also raise the possibility that left BLA-IL circuitry may contribute in mediating auditory fear memory extinction via underlying mechanisms, however further research is required.  
کلیدواژه‌های انگلیسی مقاله Extiction of auditory fear conditioning
نویسندگان مقاله | Abbas Ali Vafaei
Laboratory of Learning and Memory, Research Center of Physiology, Department of Physiology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.


| Ali Rashidy-Pour
Laboratory of Learning and Memory, Research Center of Physiology, Department of Physiology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.


| Parnia Trahomi
Student Research Committee, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.


| Samira Omoomi
Student Research Committee, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.


| Masoomeh Dadkhah
Pharmaceutical Sciences Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-2161-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Behavioral Neuroscience
نوع مقاله منتشر شده Original
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