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Iranian Journal of Public Health، جلد ۵۱، شماره ۵، صفحات ۱۰۹۷-۱۱۰۶
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عنوان انگلیسی Phyto-Fabrication of Silver Nanoparticles Using Typha azerbaijanensis Aerial Part and Root Extracts
چکیده انگلیسی مقاله Background: Silver nanoparticles (AgNPs) were phyto-synthesized using Typha azerbaijanensis aerial part and root extracts, and their biological activities were investigated. Methods: This study was conducted in the Science and Research Branch, Islamic Azad University, Tehran, Iran in 2019. In this experimental study, silver nanoparticles (AgNPs) were phyto-synthesized and the physicochemical properties of AgNPs were determined using UV-Vis (UV-Vis) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and Fourier transform infrared (FTIR) spectroscopy. Antibacterial and anticancer activity of synthesized AgNPs was determined using microdilution assay, and MTT 3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) methods, respectively. The apoptotic effects of AgNPs were investigated using Real-Time PCR and flow cytometry techniques. Results: Morphological analysis of the synthesized AgNPs confirmed the spherical shape of AgNPs with an average size of 10.67 to 16.69 nm. The FTIR spectrum confirmed the presence of phytochemicals from T. azerbayenensis extract at the AgNP surface. Antibacterial experiments showed that phyto-fabricated AgNPs had significant antibacterial activity against Gram-negative bacteria. The AgNPs were significantly cytotoxic against breast cancer cell line (MCF-7) through induction of apoptosis.  Conclusion: The phyto-synthesized AgNPs had biological activities could be useful in pharmaceutical applications.  
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نویسندگان مقاله | Amir Mirzaie
Department of Biology, Parand Branch, Islamic Azad University, Parand, Iran


| Farzad Badmasti
Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran


| Hedieh Dibah
Department of Biology, Roudehen Branch, Islamic Azad University, Roudehen, Iran


| Shadi Hajrasouliha
Department of Biology, Roudehen Branch, Islamic Azad University, Roudehen, Iran


| Fatemeh Yousefi
Department of Biology, Roudehen Branch, Islamic Azad University, Roudehen, Iran


| Romina Andalibi
Department of Biology, Medical Science Branch, Islamic Azad University, Tehran, Iran


| Aliasghar Bagheri Kashtali
Department of Biology, Roudehen Branch, Islamic Azad University, Roudehen, Iran


| Amir Hossein Rezaei
Department of Research and Development, Production and Research Complex, Pasteur Institute of Iran, Tehran, Iran


| Ronak Bakhtiatri
Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/25469
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