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Middle East Journal of Cancer، جلد ۱۳، شماره ۲، صفحات ۲۸۵-۲۹۲
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عنوان انگلیسی Assessment of Essential and Non-essential Elements as Risk Evaluation Indices in Men with Prostate Cancer in Calabar South-South Nigeria
چکیده انگلیسی مقاله Background: Heavy metal (HM) toxicity has been described as a risk factor for the development of prostate disease in men and its assessment could predict susceptibility to prostate cancer (PCa). The current study aimed to assess the levels of HM (selenium [Se], copper [Cu], chromium [Cr] and lead [Pb], iron [Fe], zinc [Zn], magnesium [Mg], and cobalt [Co]) in men with PCa. Method: 90 men aged 40 to 75 years, including 30 men with PCa, 30 with benign prostatic hyperplasia (BPH), and 30 controls, were recruited in this case-control study. Prostate specific antigen (PSA) was estimated via enzyme linked immunosorbent assay and heavy metals with atomic absorption spectrophotometry. Body mass index (BMI) was also determined. Results: The men with PCa had significantly higher BMI, PSA, Fe, and Pb and lower Mg, Zn, Cu, and Se compared with the controls. They also had higher PSA, Fe, and Co compared with the BPH (P < 0.05). Those with BPH had higher BMI, PSA, and Fe and lower Mg, Zn, Cu, Se, and Co compared with the controls (P < 0.05). Zn was positively correlated with Mg (r = 0.937, P < 0.001, Cu (r = 0.548, P = 0.002), Se (r = 0.731, P < 0.001), and Co (r=0.733, P < 0.001) only in the men with PCa. Levels of Cu, Mg, and Se were associated with the risk of BPH and PCa. Conclusion: The men with prostate disease were found to have higher levels of lead and iron and lower magnesium, copper, selenium, and zinc, which necessitate assessment of these elements for early detection of prostate cancer and monitoring the progression of the disease.
کلیدواژه‌های انگلیسی مقاله Metals, Heavy, Prostate, Neoplasms
نویسندگان مقاله Augusta Chinyere Nsonwu-Anyanwu |
Department of Medical Laboratory Science, University of Calabar, Calabar, Nigeria

Bassey Edward Icha |
Department of Chemical Pathology, University of Calabar Teaching Hospital, Calabar, Nigeria

Magnus Chinonye Nsonwu |
Department of Optometry, Imo State University, Owerri, Nigeria

Mbetobong Ime William |
Department of Medical Laboratory Science, University of Calabar, Calabar, Nigeria

Krukru Stephen Emughupogh |
Department of Medical Laboratory Science, University of Calabar, Calabar, Nigeria

Chinyere Adanna Opara Usoro |
Department of Medical Laboratory Science, University of Calabar, Calabar, Nigeria

نشانی اینترنتی https://mejc.sums.ac.ir/article_47732_152d318abe80dd8195bd0cef4df897da.pdf
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