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Middle East Journal of Digestive Diseases، جلد ۱، شماره ۱، صفحات ۹۶-۱۰۲
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عنوان انگلیسی Evaluation of Inflammatory Cytokine and Anti Helicobacter Pylori Antibodies in the Pathogenesis of Parkinson’s Disease
چکیده انگلیسی مقاله BACKGROUND: Parkinson’s disease is a neurodegenerative disorder characterized by degeneration of dopaminergic neurons in the substantia nigari. Previous studies have shown that Helicobacter pylori (H. pylori) infection is associated with treatment and clinical response to Parkinson’s disease. In the present study, we aimed to investigate the effect of H. pylori infection in the pathogenesis of Parkinson’s disease. METHODS: 75 patients who suffered from Parkinson’s disease and H. pylori infection and 91 healthy controls were recruited. All the subjects were evaluated for serum IgM, IgG, and IgA antibodies as well as TNF-α, IL-6, and IL-4 cytokines by Enzyme-Linked ImmunoSorbent Assay (ELISA )methods. RESULTS: The participants included 102 men and 64 women with a mean age of 66±10.2 and 52.6±10.7 years in the patients and control groups, respectively. The level of IgG, TNF-α, IL-6 in the patients with Parkinson’s infected with H. pylori was significantly more than that in the control group. In contrast, IgA was significantly lower in patients with Parkinson's disease compared with the control group. CONCLUSION: Probably, persistent infection with H. pylori could be effective in the pathogenesis of Parkinson's disease by dominating the systemic inflammatory profile. It is suggested that pro-inflammatory cytokines followed by H. pylori infection through the promotion of immune response or neurotoxicity might have a role in the pathogenesis of Parkinson's disease.
کلیدواژه‌های انگلیسی مقاله Parkinson&,#039,s disease,Helicobacter pylori,Pro-inflammatory cytokines,Anti H. pylori antibodies
نویسندگان مقاله | Seyedeh Azra Shamsdin
Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


| Hajar Khazraei


| Abass Rahimi Jaberi
Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


| Mozhdeh Zamani
Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


| Mohammad Rafiee Monjezi


نشانی اینترنتی http://mejdd.org/index.php/mejdd/article/view/2380
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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